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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Leuk+Lymphoma 2020 ; 61 (12): 2900-2904 Nephropedia Template TP
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Consensus minimum hemoglobin level above which patients with myelodysplastic syndromes can safely forgo transfusions #MMPMID32667230
Tanasijevic AM; Revette A; Klepin HD; Zeidan A; Townsley D; DiNardo CD; Sebert M; DeZern AE; Stone RM; Magnavita ES; Chen R; Sekeres MA; Abel GA
Leuk Lymphoma 2020[Dec]; 61 (12): 2900-2904 PMID32667230show ga
The anemia of MDS often results in decreased quality of life, which is invoked to justify red cell transfusions; however, there are sparse data regarding the minimum hemoglobin (Hb) at which it is safe to forgo transfusions for patients with no evidence of end-organ damage. This issue is even more important in the COVID-19 era, where decreases in blood donations have stressed the blood supply. In March 2018, using a modified Delphi method, we convened a panel of 13 expert MDS clinicians for three iterative rounds to discuss a minimum safe Hb for this population. While the panel was unable to reach the pre-set consensus of 75% for a specific Hb threshold, there was 100% consensus that it be no greater than 7.5 g/dL. Our data suggest that, given no end-organ effects of anemia, patients with MDS can safely forgo transfusions with a Hb of 7.5 g/dL or higher.