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10.1177/1740774520940227 http://scihub22266oqcxt.onion/10.1177/1740774520940227 32666816!ä!32666816 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Trials 2020 ; 17 (5): 483-490 Nephropedia Template TP {{tp|p=32666816|t=2020. Highly efficient clinical trial designs for reliable screening of under-performing treatments: Application to the COVID-19 Pandemic |pdf=|usr=}}{{32666816}} gab.com Text Highly efficient clinical trial designs for reliable screening of under-performing treatments: Application to the COVID-19 Pandemic JO: Clin Trials http://www.kidney.de/pget.php?&tw=1&pmid=32666816 #FOAvip BACKGROUND: The COVID-19 pandemic presents challenges for clinical trials including urgency, disrupted infrastructure, numerous therapeutic candidates, and the need for highly efficient trial and development designs. This paper presents design components and rationale for constructing highly efficient trials to screen potential COVID-19 treatments. METHODS: Key trial design elements useful in this circumstance include futility hypotheses, treatment pooling, reciprocal controls, ranking and selection, and platform administration. Assuming most of the many candidates for COVID-19 treatment are likely to be ineffective, these components can be combined to facilitate very efficient comparisons of treatments. RESULTS: Simulations indicate such designs can reliably discard underperforming treatments using sample size to treatment ratios under 30. CONCLUSIONS: Methods to create very efficient clinical trial comparisons of treatments for COVID-19 are available. Such designs might be helpful in the pandemic and should be considered for similar needs in the future. Twit Text FOAVip Highly efficient clinical trial designs for reliable screening of under-performing treatments: Application to the COVID-19 Pandemic ????Clin Trials http://www.kidney.de/pget.php?&tw=1&pmid=32666816 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32666816 #FOAvip English Wikipedia <ref>{{Cite pmid|32666816}}</ref> Highly efficient clinical trial designs for reliable screening of under-performing treatments: Application to the COVID-19 Pandemic #MMPMID32666816 Piantadosi S Clin Trials 2020[Oct]; 17 (5): 483-490 PMID32666816show ga BACKGROUND: The COVID-19 pandemic presents challenges for clinical trials including urgency, disrupted infrastructure, numerous therapeutic candidates, and the need for highly efficient trial and development designs. This paper presents design components and rationale for constructing highly efficient trials to screen potential COVID-19 treatments. METHODS: Key trial design elements useful in this circumstance include futility hypotheses, treatment pooling, reciprocal controls, ranking and selection, and platform administration. Assuming most of the many candidates for COVID-19 treatment are likely to be ineffective, these components can be combined to facilitate very efficient comparisons of treatments. RESULTS: Simulations indicate such designs can reliably discard underperforming treatments using sample size to treatment ratios under 30. CONCLUSIONS: Methods to create very efficient clinical trial comparisons of treatments for COVID-19 are available. Such designs might be helpful in the pandemic and should be considered for similar needs in the future. |*Betacoronavirus[MESH] |COVID-19[MESH] |Clinical Trials as Topic/*methods[MESH] |Coronavirus Infections/epidemiology/*therapy[MESH] |Delivery of Health Care/*methods[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/epidemiology/*therapy[MESH]Highly efficient clinical trial designs for reliable screening of und(epmc).pdf DeepDyve Pubget Overpricing