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10.1111/jep.13438 http://scihub22266oqcxt.onion/10.1111/jep.13438 32666676!7405225!32666676     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Eval+Clin+Pract 2021 ; 27 (3): 684-693 Nephropedia Template TP {{tp|p=32666676|t=2021. The use of mechanistic reasoning in assessing coronavirus interventions |pdf=|usr=}}{{32666676}} gab.com Text The use of mechanistic reasoning in assessing coronavirus interventions JO: J Eval Clin Pract http://www.kidney.de/pget.php?&tw=1&pmid=32666676 #FOAvip RATIONALE: Evidence-based medicine (EBM), the dominant approach to assessing the effectiveness of clinical and public health interventions, focuses on the results of association studies. EBM+ is a development of EBM that systematically considers mechanistic studies alongside association studies. AIMS AND OBJECTIVES: To explore examples of the importance of mechanistic evidence to coronavirus research. METHODS: We have reviewed the mechanistic evidence in four major areas that are relevant to the management of COVID-19. RESULTS AND CONCLUSIONS: (a) Assessment of combination therapy for MERS highlights the need for systematic assessment of mechanistic evidence. (b) That hypertension is a risk factor for severe disease in the case of SARS-CoV-2 suggests that altering hypertension treatment might alleviate disease, but the mechanisms are complex, and it is essential to consider and evaluate multiple mechanistic hypotheses. (c) Confidence that public health interventions will be effective requires a detailed assessment of social and psychological components of the mechanisms of their action, in addition to mechanisms of disease. (d) In particular, if vaccination programmes are to be effective, they must be carefully tailored to the social context; again, mechanistic evidence is crucial. We conclude that coronavirus research is best situated within the EBM+ evaluation framework. Twit Text FOAVip The use of mechanistic reasoning in assessing coronavirus interventions ????J Eval Clin Pract http://www.kidney.de/pget.php?&tw=1&pmid=32666676 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32666676 #FOAvip English Wikipedia <ref>{{Cite pmid|32666676}}</ref> The use of mechanistic reasoning in assessing coronavirus interventions #MMPMID32666676 Aronson JK; Auker-Howlett D; Ghiara V; Kelly MP; Williamson J J Eval Clin Pract 2021[Jun]; 27 (3): 684-693 PMID32666676show ga RATIONALE: Evidence-based medicine (EBM), the dominant approach to assessing the effectiveness of clinical and public health interventions, focuses on the results of association studies. EBM+ is a development of EBM that systematically considers mechanistic studies alongside association studies. AIMS AND OBJECTIVES: To explore examples of the importance of mechanistic evidence to coronavirus research. METHODS: We have reviewed the mechanistic evidence in four major areas that are relevant to the management of COVID-19. RESULTS AND CONCLUSIONS: (a) Assessment of combination therapy for MERS highlights the need for systematic assessment of mechanistic evidence. (b) That hypertension is a risk factor for severe disease in the case of SARS-CoV-2 suggests that altering hypertension treatment might alleviate disease, but the mechanisms are complex, and it is essential to consider and evaluate multiple mechanistic hypotheses. (c) Confidence that public health interventions will be effective requires a detailed assessment of social and psychological components of the mechanisms of their action, in addition to mechanisms of disease. (d) In particular, if vaccination programmes are to be effective, they must be carefully tailored to the social context; again, mechanistic evidence is crucial. We conclude that coronavirus research is best situated within the EBM+ evaluation framework. |*Clinical Reasoning[MESH] |*Evidence-Based Medicine[MESH] |COVID-19/*therapy[MESH] |Humans[MESH] |Hypertension/therapy[MESH] |Public Health[MESH]The use of mechanistic reasoning in assessing coronavirus intervention(epmc).pdf DeepDyve Pubget Overpricing