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10.1007/s00296-020-04639-9

http://scihub22266oqcxt.onion/10.1007/s00296-020-04639-9
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32666137!7360125!32666137
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suck abstract from ncbi


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pmid32666137      Rheumatol+Int 2020 ; 40 (10): 1539-1554
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  • Autoimmune and rheumatic musculoskeletal diseases as a consequence of SARS-CoV-2 infection and its treatment #MMPMID32666137
  • Shah S; Danda D; Kavadichanda C; Das S; Adarsh MB; Negi VS
  • Rheumatol Int 2020[Oct]; 40 (10): 1539-1554 PMID32666137show ga
  • The coronavirus disease-2019 (COVID-19) pandemic is likely to pose new challenges to the rheumatology community in the near and distant future. Some of the challenges, like the severity of COVID-19 among patients on immunosuppressive agents, are predictable and are being evaluated with great care and effort across the globe. A few others, such as atypical manifestations of COVID-19 mimicking rheumatic musculoskeletal diseases (RMDs) are being reported. Like in many other viral infections, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can potentially lead to an array of rheumatological and autoimmune manifestations by molecular mimicry (cross-reacting epitope between the virus and the host), bystander killing (virus-specific CD8 + T cells migrating to the target tissues and exerting cytotoxicity), epitope spreading, viral persistence (polyclonal activation due to the constant presence of viral antigens driving immune-mediated injury) and formation of neutrophil extracellular traps. In addition, the myriad of antiviral drugs presently being tried in the treatment of COVID-19 can result in several rheumatic musculoskeletal adverse effects. In this review, we have addressed the possible spectrum and mechanisms of various autoimmune and rheumatic musculoskeletal manifestations that can be precipitated by COVID-19 infection, its therapy, and the preventive strategies to contain the infection.
  • |Antibodies, Antinuclear/immunology[MESH]
  • |Antibodies, Antiphospholipid/immunology[MESH]
  • |Antiviral Agents/adverse effects[MESH]
  • |Arthralgia/etiology/immunology/physiopathology[MESH]
  • |Autoimmune Diseases/etiology/immunology/*physiopathology[MESH]
  • |Betacoronavirus[MESH]
  • |Blood Coagulation Disorders/etiology/immunology/physiopathology[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/complications/drug therapy/immunology/*physiopathology[MESH]
  • |Cross Reactions/immunology[MESH]
  • |Extracellular Traps/immunology[MESH]
  • |Fibrin Fibrinogen Degradation Products[MESH]
  • |Guillain-Barre Syndrome/etiology/immunology/physiopathology[MESH]
  • |Humans[MESH]
  • |Lupus Coagulation Inhibitor/immunology[MESH]
  • |Molecular Mimicry[MESH]
  • |Mucocutaneous Lymph Node Syndrome/etiology/immunology/physiopathology[MESH]
  • |Muscle Weakness/etiology/immunology/physiopathology[MESH]
  • |Musculoskeletal Diseases/etiology/immunology/*physiopathology[MESH]
  • |Myalgia/etiology/immunology/physiopathology[MESH]
  • |Myocarditis/etiology/immunology/physiopathology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/complications/drug therapy/immunology/*physiopathology[MESH]
  • |Rheumatic Diseases/etiology/immunology/*physiopathology[MESH]


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