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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 ACS+Med+Chem+Lett 2020 ; 11 (7): 1361-1366 Nephropedia Template TP
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Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment #MMPMID32665809
Yan VC; Muller FL
ACS Med Chem Lett 2020[Jul]; 11 (7): 1361-1366 PMID32665809show ga
While remdesivir has garnered much hope for its moderate anti-Covid-19 effects, its parent nucleoside, GS-441524, has been overlooked. Pharmacokinetic analysis of remdesivir evidences premature serum hydrolysis to GS-441524; GS-441524 is the predominant metabolite reaching the lungs. With its synthetic simplicity and in vivo efficacy in the veterinary setting, we contend that GS-441524 is superior to remdesivir for Covid-19 treatment.