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10.1038/s41467-020-17189-2 http://scihub22266oqcxt.onion/10.1038/s41467-020-17189-2 32665542!7360763!32665542     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 3518 Nephropedia Template TP {{tp|p=32665542|t=2020. Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing |pdf=|usr=}}{{32665542}} gab.com Text Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32665542 #FOAvip Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Various studies exist about the molecular mechanisms of viral infection. However, such information is spread across many publications and it is very time-consuming to integrate, and exploit. We develop CoVex, an interactive online platform for SARS-CoV-2 host interactome exploration and drug (target) identification. CoVex integrates virus-human protein interactions, human protein-protein interactions, and drug-target interactions. It allows visual exploration of the virus-host interactome and implements systems medicine algorithms for network-based prediction of drug candidates. Thus, CoVex is a resource to understand molecular mechanisms of pathogenicity and to prioritize candidate therapeutics. We investigate recent hypotheses on a systems biology level to explore mechanistic virus life cycle drivers, and to extract drug repurposing candidates. CoVex renders COVID-19 drug research systems-medicine-ready by giving the scientific community direct access to network medicine algorithms. It is available at https://exbio.wzw.tum.de/covex/. Twit Text FOAVip Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32665542 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32665542 #FOAvip English Wikipedia <ref>{{Cite pmid|32665542}}</ref> Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing #MMPMID32665542 Sadegh S; Matschinske J; Blumenthal DB; Galindez G; Kacprowski T; List M; Nasirigerdeh R; Oubounyt M; Pichlmair A; Rose TD; Salgado-Albarran M; Spath J; Stukalov A; Wenke NK; Yuan K; Pauling JK; Baumbach J Nat Commun 2020[Jul]; 11 (1): 3518 PMID32665542show ga Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Various studies exist about the molecular mechanisms of viral infection. However, such information is spread across many publications and it is very time-consuming to integrate, and exploit. We develop CoVex, an interactive online platform for SARS-CoV-2 host interactome exploration and drug (target) identification. CoVex integrates virus-human protein interactions, human protein-protein interactions, and drug-target interactions. It allows visual exploration of the virus-host interactome and implements systems medicine algorithms for network-based prediction of drug candidates. Thus, CoVex is a resource to understand molecular mechanisms of pathogenicity and to prioritize candidate therapeutics. We investigate recent hypotheses on a systems biology level to explore mechanistic virus life cycle drivers, and to extract drug repurposing candidates. CoVex renders COVID-19 drug research systems-medicine-ready by giving the scientific community direct access to network medicine algorithms. It is available at https://exbio.wzw.tum.de/covex/. |Algorithms[MESH] |Antiviral Agents/*therapeutic use[MESH] |Betacoronavirus/*drug effects[MESH] |COVID-19[MESH] |Computer Simulation[MESH] |Coronavirus Infections/*drug therapy[MESH] |Drug Repositioning/*methods[MESH] |Host Microbial Interactions/*physiology[MESH] |Humans[MESH] |Internet[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy[MESH] |Protein Interaction Maps[MESH] |SARS-CoV-2[MESH]Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurpos(epmc).pdf DeepDyve Pubget Overpricing