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10.1186/s12916-020-01682-y http://scihub22266oqcxt.onion/10.1186/s12916-020-01682-y 32664932!7360379!32664932     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Med 2020 ; 18 (1): 214 Nephropedia Template TP {{tp|p=32664932|t=2020. Could hemophagocytic lymphohistiocytosis be the core issue of severe COVID-19 cases?|pdf=|usr=}}{{32664932}} gab.com Text Could hemophagocytic lymphohistiocytosis be the core issue of severe COVID-19 cases JO: BMC Med http://www.kidney.de/pget.php?&tw=1&pmid=32664932 #FOAvip BACKGROUND: COVID-19, a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), commonly presents as fever, cough, dyspnea, and myalgia or fatigue. Although the majority of patients with COVID-19 have mild symptoms, some are more prone to serious outcomes, including pneumonia, acute respiratory distress syndrome (ARDS), and even death. Hemophagocytic lymphohistiocytosis (HLH) is a severe, life-threatening inflammatory syndrome associated with intense cytokine release (also known as a "cytokine storm"). Similar to COVID-19, HLH is characterized by aggressive course leading to multi-organ failure. MAIN TEXT: The purpose of this review article is to draw attention to the possibility of the complication of HLH in patients with the severe course of COVID-19. Indeed, some of the clinical characteristics observed in the more severe cases of COVID-19 are reminiscent of secondary HLH (which can be triggered by infections, malignancies, rheumatological diseases, or autoimmune/immunodeficiency conditions). The pathogenesis of SARS-CoV-2 infection also suggests that HLH or a similar hyperinflammatory syndrome is the cause of the severe course of the infection. CONCLUSION: The pathogenesis and clinical symptoms of severe COVID-19 indicate that an increased inflammatory response corresponding to HLH is occurring. Therefore, patients with severe COVID-19 should be screened for hyperinflammation using standard laboratory tests to identify those for whom immunosuppressive therapy may improve outcomes. Twit Text FOAVip Could hemophagocytic lymphohistiocytosis be the core issue of severe COVID-19 cases ????BMC Med http://www.kidney.de/pget.php?&tw=1&pmid=32664932 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32664932 #FOAvip English Wikipedia <ref>{{Cite pmid|32664932}}</ref> Could hemophagocytic lymphohistiocytosis be the core issue of severe COVID-19 cases? #MMPMID32664932 Opoka-Winiarska V; Grywalska E; Rolinski J BMC Med 2020[Jul]; 18 (1): 214 PMID32664932show ga BACKGROUND: COVID-19, a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), commonly presents as fever, cough, dyspnea, and myalgia or fatigue. Although the majority of patients with COVID-19 have mild symptoms, some are more prone to serious outcomes, including pneumonia, acute respiratory distress syndrome (ARDS), and even death. Hemophagocytic lymphohistiocytosis (HLH) is a severe, life-threatening inflammatory syndrome associated with intense cytokine release (also known as a "cytokine storm"). Similar to COVID-19, HLH is characterized by aggressive course leading to multi-organ failure. MAIN TEXT: The purpose of this review article is to draw attention to the possibility of the complication of HLH in patients with the severe course of COVID-19. Indeed, some of the clinical characteristics observed in the more severe cases of COVID-19 are reminiscent of secondary HLH (which can be triggered by infections, malignancies, rheumatological diseases, or autoimmune/immunodeficiency conditions). The pathogenesis of SARS-CoV-2 infection also suggests that HLH or a similar hyperinflammatory syndrome is the cause of the severe course of the infection. CONCLUSION: The pathogenesis and clinical symptoms of severe COVID-19 indicate that an increased inflammatory response corresponding to HLH is occurring. Therefore, patients with severe COVID-19 should be screened for hyperinflammation using standard laboratory tests to identify those for whom immunosuppressive therapy may improve outcomes. |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications/therapy[MESH] |Cytokine Release Syndrome/*virology[MESH] |Humans[MESH] |Lymphohistiocytosis, Hemophagocytic/diagnosis/therapy/*virology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/therapy[MESH]Could hemophagocytic lymphohistiocytosis be the core issue of severe C(epmc).pdf DeepDyve Pubget Overpricing