Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3390/ijms21144907 http://scihub22266oqcxt.onion/10.3390/ijms21144907 32664570!7404035!32664570     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32664570.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2020 ; 21 (14): ä Nephropedia Template TP {{tp|p=32664570|t=2020. Polymorphic Forms of Valinomycin Investigated by NMR Crystallography |pdf=|usr=}}{{32664570}} gab.com Text Polymorphic Forms of Valinomycin Investigated by NMR Crystallography JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32664570 #FOAvip A dodecadepsipeptide valinomycin (VLM) has been most recently reported to be a potential anti-coronavirus drug that could be efficiently produced on a large scale. It is thus of importance to study solid-phase forms of VLM in order to be able to ensure its polymorphic purity in drug formulations. The previously available solid-state NMR (SSNMR) data are combined with the plane-wave DFT computations in the NMR crystallography framework. Structural/spectroscopical predictions (the PBE functional/GIPAW method) are obtained to characterize four polymorphs of VLM. Interactions which confer a conformational stability to VLM molecules in these crystalline forms are described in detail. The way how various structural factors affect the values of SSNMR parameters is thoroughly analyzed, and several SSNMR markers of the respective VLM polymorphs are identified. The markers are connected to hydrogen bonding effects upon the corresponding ((13)C/(15)N/(1)H) isotropic chemical shifts of (C(O), N(amid), H(amid), H(alpha)) VLM backbone nuclei. These results are expected to be crucial for polymorph control of VLM and in probing its interactions in dosage forms. Twit Text FOAVip Polymorphic Forms of Valinomycin Investigated by NMR Crystallography ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32664570 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32664570 #FOAvip English Wikipedia <ref>{{Cite pmid|32664570}}</ref> Polymorphic Forms of Valinomycin Investigated by NMR Crystallography #MMPMID32664570 Czernek J; Brus J Int J Mol Sci 2020[Jul]; 21 (14): ä PMID32664570show ga A dodecadepsipeptide valinomycin (VLM) has been most recently reported to be a potential anti-coronavirus drug that could be efficiently produced on a large scale. It is thus of importance to study solid-phase forms of VLM in order to be able to ensure its polymorphic purity in drug formulations. The previously available solid-state NMR (SSNMR) data are combined with the plane-wave DFT computations in the NMR crystallography framework. Structural/spectroscopical predictions (the PBE functional/GIPAW method) are obtained to characterize four polymorphs of VLM. Interactions which confer a conformational stability to VLM molecules in these crystalline forms are described in detail. The way how various structural factors affect the values of SSNMR parameters is thoroughly analyzed, and several SSNMR markers of the respective VLM polymorphs are identified. The markers are connected to hydrogen bonding effects upon the corresponding ((13)C/(15)N/(1)H) isotropic chemical shifts of (C(O), N(amid), H(amid), H(alpha)) VLM backbone nuclei. These results are expected to be crucial for polymorph control of VLM and in probing its interactions in dosage forms. |Betacoronavirus/chemistry/isolation & purification/metabolism[MESH] |COVID-19[MESH] |Carbon Isotopes/chemistry[MESH] |Coronavirus Infections/pathology/virology[MESH] |Crystallography[MESH] |Hydrogen Bonding[MESH] |Magnetic Resonance Spectroscopy/*methods[MESH] |Nitrogen Isotopes/chemistry[MESH] |Pandemics[MESH] |Pneumonia, Viral/pathology/virology[MESH] |SARS-CoV-2[MESH]Polymorphic Forms of Valinomycin Investigated by NMR Crystallography (epmc).pdf DeepDyve Pubget Overpricing