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10.1016/j.dsx.2020.07.005

http://scihub22266oqcxt.onion/10.1016/j.dsx.2020.07.005
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suck abstract from ncbi


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pmid32663789      Diabetes+Metab+Syndr 2020 ; 14 (5): 1133-1142
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  • Association of hypertension, diabetes, stroke, cancer, kidney disease, and high-cholesterol with COVID-19 disease severity and fatality: A systematic review #MMPMID32663789
  • Zaki N; Alashwal H; Ibrahim S
  • Diabetes Metab Syndr 2020[Sep]; 14 (5): 1133-1142 PMID32663789show ga
  • BACKGROUND AND AIMS: To undertake a review and critical appraisal of published/preprint reports that offer methods of determining the effects of hypertension, diabetes, stroke, cancer, kidney issues, and high-cholesterol on COVID-19 disease severity. METHODS: A search was conducted by two authors independently on the freely available COVID-19 Open Research Dataset (CORD-19). We developed an automated search engine to screen a total of 59,000 articles in a few seconds. Filtering of the articles was then undertaken using keywords and questions, e.g. "Effects of diabetes on COVID/normal coronavirus/SARS-CoV-2/nCoV/COVID-19 disease severity, mortality?". The search terms were repeated for all the comorbidities considered in this paper. Additional articles were retrieved by searching via Google Scholar and PubMed. FINDINGS: A total of 54 articles were considered for a full review. It was observed that diabetes, hypertension, and cholesterol levels possess an apparent relation to COVID-19 severity. Other comorbidities, such as cancer, kidney disease, and stroke, must be further evaluated to determine a strong relationship to the virus. CONCLUSION: Reports associating cancer, kidney disease, and stroke with COVID-19 should be carefully interpreted, not only because of the size of the samples, but also because patients could be old, have a history of smoking, or have any other clinical condition suggesting that these factors might be associated with the poor COVID-19 outcomes rather than the comorbidity itself. Further research regarding this relationship and its clinical management is warranted.
  • |*Severity of Illness Index[MESH]
  • |Betacoronavirus/*isolation & purification[MESH]
  • |COVID-19[MESH]
  • |Cholesterol/*metabolism[MESH]
  • |Coronavirus Infections/epidemiology/*mortality/virology[MESH]
  • |Diabetes Mellitus/*physiopathology/virology[MESH]
  • |Humans[MESH]
  • |Hypertension/*physiopathology/virology[MESH]
  • |Kidney Diseases/*physiopathology/virology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/epidemiology/*mortality/virology[MESH]
  • |Prognosis[MESH]
  • |SARS-CoV-2[MESH]
  • |Stroke/*physiopathology/virology[MESH]


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