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10.1021/acschemneuro.0c00391 http://scihub22266oqcxt.onion/10.1021/acschemneuro.0c00391 32662982!ä!32662982 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Chem+Neurosci 2020 ; 11 (15): 2145-2148 Nephropedia Template TP {{tp|p=32662982|t=2020. Calcium Channel Blockers: A Possible Potential Therapeutic Strategy for the Treatment of Alzheimer s Dementia Patients with SARS-CoV-2 Infection |pdf=|usr=}}{{32662982}} gab.com Text Calcium Channel Blockers: A Possible Potential Therapeutic Strategy for the Treatment of Alzheimer s Dementia Patients with SARS-CoV-2 Infection JO: ACS Chem Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=32662982 #FOAvip Studies have shown that the calcium ion (Ca(2+)) plays important roles both in Alzheimer's dementia and SARS-CoV S-mediated fusion to host cell entry. An elevated level of intracellular calcium causes neuronal dysfunction, cell death, and apoptosis. Dysregulation of calcium has also been shown to increase the production of amyloid beta (Abeta) protein, the hallmark of Alzheimer's dementia. Reversely, deposition of Abeta is also responsible for calcium dysregulation. On the other hand, it has been well investigated that viruses can disturb host cell Ca(2+) homeostasis as well as modulate signal transduction mechanisms. Viruses can also hijack the host cell calcium channels and pumps to release more intracellular Ca(2+) to utilize for their life cycle. Even though evidence has not been reported on SARS-CoV-2 concerning Ca(2+) regulation, however, it has been well established that Ca(2+) is essential for viral entry, viral gene replication, and virion maturation and release. Recent reports suggest that SARS-CoV needs two Ca(2+) ions to fuse with the host cell at the entry step. Furthermore, some calcium channel blockers (CCBs), such as nimodipine, memantine, etc., have been reported to be effective in the treatment of dementia in Alzheimer's disease (AD) as well as have shown inhibition in various virus infections. Twit Text FOAVip Calcium Channel Blockers: A Possible Potential Therapeutic Strategy for the Treatment of Alzheimer s Dementia Patients with SARS-CoV-2 Infection ????ACS Chem Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=32662982 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32662982 #FOAvip English Wikipedia <ref>{{Cite pmid|32662982}}</ref> Calcium Channel Blockers: A Possible Potential Therapeutic Strategy for the Treatment of Alzheimer s Dementia Patients with SARS-CoV-2 Infection #MMPMID32662982 Danta CC ACS Chem Neurosci 2020[Aug]; 11 (15): 2145-2148 PMID32662982show ga Studies have shown that the calcium ion (Ca(2+)) plays important roles both in Alzheimer's dementia and SARS-CoV S-mediated fusion to host cell entry. An elevated level of intracellular calcium causes neuronal dysfunction, cell death, and apoptosis. Dysregulation of calcium has also been shown to increase the production of amyloid beta (Abeta) protein, the hallmark of Alzheimer's dementia. Reversely, deposition of Abeta is also responsible for calcium dysregulation. On the other hand, it has been well investigated that viruses can disturb host cell Ca(2+) homeostasis as well as modulate signal transduction mechanisms. Viruses can also hijack the host cell calcium channels and pumps to release more intracellular Ca(2+) to utilize for their life cycle. Even though evidence has not been reported on SARS-CoV-2 concerning Ca(2+) regulation, however, it has been well established that Ca(2+) is essential for viral entry, viral gene replication, and virion maturation and release. Recent reports suggest that SARS-CoV needs two Ca(2+) ions to fuse with the host cell at the entry step. Furthermore, some calcium channel blockers (CCBs), such as nimodipine, memantine, etc., have been reported to be effective in the treatment of dementia in Alzheimer's disease (AD) as well as have shown inhibition in various virus infections. |*Betacoronavirus[MESH] |Alzheimer Disease/*drug therapy/metabolism/psychology[MESH] |COVID-19[MESH] |Calcium Channel Blockers/chemistry/pharmacology/*therapeutic use[MESH] |Calcium Channels/metabolism[MESH] |Calcium/metabolism[MESH] |Coronavirus Infections/*drug therapy/metabolism/psychology[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/metabolism/psychology[MESH] |SARS-CoV-2[MESH]Calcium Channel Blockers: A Possible Potential Therapeutic Strategy fo(epmc).pdf DeepDyve Pubget Overpricing