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10.7554/eLife.58716 http://scihub22266oqcxt.onion/10.7554/eLife.58716 32662421!7367681!32662421     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32662421&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2020 ; 9 (ä): ä Nephropedia Template TP {{tp|p=32662421|t=2020. Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?|pdf=|usr=}}{{32662421}} gab.com Text Does the human placenta express the canonical cell entry mediators for SARS-CoV-2 JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=32662421 #FOAvip The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected more than 10 million people, including pregnant women. To date, no consistent evidence for the vertical transmission of SARS-CoV-2 exists. The novel coronavirus canonically utilizes the angiotensin-converting enzyme 2 (ACE2) receptor and the serine protease TMPRSS2 for cell entry. Herein, building upon our previous single-cell study (Pique-Regi et al., 2019), another study, and new single-cell/nuclei RNA-sequencing data, we investigated the expression of ACE2 and TMPRSS2 throughout pregnancy in the placenta as well as in third-trimester chorioamniotic membranes. We report that co-transcription of ACE2 and TMPRSS2 is negligible in the placenta, thus not a likely path of vertical transmission for SARS-CoV-2. By contrast, receptors for Zika virus and cytomegalovirus, which cause congenital infections, are highly expressed by placental cell types. These data show that the placenta minimally expresses the canonical cell-entry mediators for SARS-CoV-2. Twit Text FOAVip Does the human placenta express the canonical cell entry mediators for SARS-CoV-2 ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=32662421 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32662421 #FOAvip English Wikipedia <ref>{{Cite pmid|32662421}}</ref> Does the human placenta express the canonical cell entry mediators for SARS-CoV-2? #MMPMID32662421 Pique-Regi R; Romero R; Tarca AL; Luca F; Xu Y; Alazizi A; Leng Y; Hsu CD; Gomez-Lopez N Elife 2020[Jul]; 9 (ä): ä PMID32662421show ga The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected more than 10 million people, including pregnant women. To date, no consistent evidence for the vertical transmission of SARS-CoV-2 exists. The novel coronavirus canonically utilizes the angiotensin-converting enzyme 2 (ACE2) receptor and the serine protease TMPRSS2 for cell entry. Herein, building upon our previous single-cell study (Pique-Regi et al., 2019), another study, and new single-cell/nuclei RNA-sequencing data, we investigated the expression of ACE2 and TMPRSS2 throughout pregnancy in the placenta as well as in third-trimester chorioamniotic membranes. We report that co-transcription of ACE2 and TMPRSS2 is negligible in the placenta, thus not a likely path of vertical transmission for SARS-CoV-2. By contrast, receptors for Zika virus and cytomegalovirus, which cause congenital infections, are highly expressed by placental cell types. These data show that the placenta minimally expresses the canonical cell-entry mediators for SARS-CoV-2. |*Virus Internalization[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/metabolism/*physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/metabolism/transmission/*virology[MESH] |Female[MESH] |Humans[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/genetics/metabolism[MESH] |Placenta/*metabolism/*virology[MESH] |Pneumonia, Viral/metabolism/*transmission/virology[MESH] |Pregnancy[MESH] |Receptors, Virus/genetics/*metabolism[MESH] |SARS-CoV-2[MESH] |Serine Endopeptidases/genetics/*metabolism[MESH] |Zika Virus[MESH]Does the human placenta express the canonical cell entry mediators for(epmc).pdf DeepDyve Pubget Overpricing