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10.1111/aji.13304 http://scihub22266oqcxt.onion/10.1111/aji.13304 32662111!7404618!32662111     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Reprod+Immunol 2020 ; 84 (5): e13304 Nephropedia Template TP {{tp|p=32662111|t=2020. COVID-19 and Treg/Th17 imbalance: Potential relationship to pregnancy outcomes |pdf=|usr=}}{{32662111}} gab.com Text COVID-19 and Treg/Th17 imbalance: Potential relationship to pregnancy outcomes JO: Am J Reprod Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32662111 #FOAvip Caused by a novel type of virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease 2019 (COVID-19) constitutes a global public health emergency. Pregnant women are considered to have a higher risk of severe morbidity and even mortality due to their susceptibility to respiratory pathogens and their particular immunologic state. Several studies assessing SARS-CoV-2 infection during pregnancy reported adverse pregnancy outcomes in patients with severe conditions, including spontaneous abortion, preterm labor, fetal distress, cesarean section, preterm birth, neonatal asphyxia, neonatal pneumonia, stillbirth, and neonatal death. However, whether these complications are causally related to SARS-CoV-2 infection is not clear. Here, we reviewed the scientific evidence supporting the contributing role of Treg/Th17 cell imbalance in the uncontrolled systemic inflammation characterizing severe cases of COVID-19. Based on the recognized harmful effects of these CD4(+) T-cell subset imbalances in pregnancy, we speculated that SARS-CoV-2 infection might lead to adverse pregnancy outcomes through the deregulation of otherwise tightly regulated Treg/Th17 ratios, and to subsequent uncontrolled systemic inflammation. Moreover, we discuss the possibility of vertical transmission of COVID-19 from infected mothers to their infants, which could also explain adverse perinatal outcomes. Rigorous monitoring of pregnancies and appropriate measures should be taken to prevent and treat early eventual maternal and perinatal complications. Twit Text FOAVip COVID-19 and Treg/Th17 imbalance: Potential relationship to pregnancy outcomes ????Am J Reprod Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32662111 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32662111 #FOAvip English Wikipedia <ref>{{Cite pmid|32662111}}</ref> COVID-19 and Treg/Th17 imbalance: Potential relationship to pregnancy outcomes #MMPMID32662111 Muyayalo KP; Huang DH; Zhao SJ; Xie T; Mor G; Liao AH Am J Reprod Immunol 2020[Nov]; 84 (5): e13304 PMID32662111show ga Caused by a novel type of virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease 2019 (COVID-19) constitutes a global public health emergency. Pregnant women are considered to have a higher risk of severe morbidity and even mortality due to their susceptibility to respiratory pathogens and their particular immunologic state. Several studies assessing SARS-CoV-2 infection during pregnancy reported adverse pregnancy outcomes in patients with severe conditions, including spontaneous abortion, preterm labor, fetal distress, cesarean section, preterm birth, neonatal asphyxia, neonatal pneumonia, stillbirth, and neonatal death. However, whether these complications are causally related to SARS-CoV-2 infection is not clear. Here, we reviewed the scientific evidence supporting the contributing role of Treg/Th17 cell imbalance in the uncontrolled systemic inflammation characterizing severe cases of COVID-19. Based on the recognized harmful effects of these CD4(+) T-cell subset imbalances in pregnancy, we speculated that SARS-CoV-2 infection might lead to adverse pregnancy outcomes through the deregulation of otherwise tightly regulated Treg/Th17 ratios, and to subsequent uncontrolled systemic inflammation. Moreover, we discuss the possibility of vertical transmission of COVID-19 from infected mothers to their infants, which could also explain adverse perinatal outcomes. Rigorous monitoring of pregnancies and appropriate measures should be taken to prevent and treat early eventual maternal and perinatal complications. |COVID-19/*immunology/transmission[MESH] |Female[MESH] |Humans[MESH] |Infectious Disease Transmission, Vertical[MESH] |Pandemics[MESH] |Pregnancy Complications, Infectious/*immunology[MESH] |Pregnancy Outcome[MESH] |Pregnancy/*immunology[MESH] |SARS-CoV-2/*physiology[MESH] |T-Lymphocytes, Regulatory/*immunology[MESH]COVID-19 and Treg/Th17 imbalance: Potential relationship to pregnancy (epmc).pdf DeepDyve Pubget Overpricing