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10.1038/s41591-020-0995-0 http://scihub22266oqcxt.onion/10.1038/s41591-020-0995-0 32661393!ä!32661393 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2020 ; 26 (9): 1428-1434 Nephropedia Template TP {{tp|p=32661393|t=2020. Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19 |pdf=|usr=}}{{32661393}} gab.com Text Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19 JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=32661393 #FOAvip The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has dramatically expedited global vaccine development efforts(1-3), most targeting the viral 'spike' glycoprotein (S). S localizes on the virion surface and mediates recognition of cellular receptor angiotensin-converting enzyme 2 (ACE2)(4-6). Eliciting neutralizing antibodies that block S-ACE2 interaction(7-9), or indirectly prevent membrane fusion(10), constitute an attractive modality for vaccine-elicited protection(11). However, although prototypic S-based vaccines show promise in animal models(12-14), the immunogenic properties of S in humans are poorly resolved. In this study, we characterized humoral and circulating follicular helper T cell (cTFH) immunity against spike in recovered patients with coronavirus disease 2019 (COVID-19). We found that S-specific antibodies, memory B cells and cTFH are consistently elicited after SARS-CoV-2 infection, demarking robust humoral immunity and positively associated with plasma neutralizing activity. Comparatively low frequencies of B cells or cTFH specific for the receptor binding domain of S were elicited. Notably, the phenotype of S-specific cTFH differentiated subjects with potent neutralizing responses, providing a potential biomarker of potency for S-based vaccines entering the clinic. Overall, although patients who recovered from COVID-19 displayed multiple hallmarks of effective immune recognition of S, the wide spectrum of neutralizing activity observed suggests that vaccines might require strategies to selectively target the most potent neutralizing epitopes. Twit Text FOAVip Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19 ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=32661393 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32661393 #FOAvip English Wikipedia <ref>{{Cite pmid|32661393}}</ref> Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19 #MMPMID32661393 Juno JA; Tan HX; Lee WS; Reynaldi A; Kelly HG; Wragg K; Esterbauer R; Kent HE; Batten CJ; Mordant FL; Gherardin NA; Pymm P; Dietrich MH; Scott NE; Tham WH; Godfrey DI; Subbarao K; Davenport MP; Kent SJ; Wheatley AK Nat Med 2020[Sep]; 26 (9): 1428-1434 PMID32661393show ga The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has dramatically expedited global vaccine development efforts(1-3), most targeting the viral 'spike' glycoprotein (S). S localizes on the virion surface and mediates recognition of cellular receptor angiotensin-converting enzyme 2 (ACE2)(4-6). Eliciting neutralizing antibodies that block S-ACE2 interaction(7-9), or indirectly prevent membrane fusion(10), constitute an attractive modality for vaccine-elicited protection(11). However, although prototypic S-based vaccines show promise in animal models(12-14), the immunogenic properties of S in humans are poorly resolved. In this study, we characterized humoral and circulating follicular helper T cell (cTFH) immunity against spike in recovered patients with coronavirus disease 2019 (COVID-19). We found that S-specific antibodies, memory B cells and cTFH are consistently elicited after SARS-CoV-2 infection, demarking robust humoral immunity and positively associated with plasma neutralizing activity. Comparatively low frequencies of B cells or cTFH specific for the receptor binding domain of S were elicited. Notably, the phenotype of S-specific cTFH differentiated subjects with potent neutralizing responses, providing a potential biomarker of potency for S-based vaccines entering the clinic. Overall, although patients who recovered from COVID-19 displayed multiple hallmarks of effective immune recognition of S, the wide spectrum of neutralizing activity observed suggests that vaccines might require strategies to selectively target the most potent neutralizing epitopes. |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Antibodies, Neutralizing/immunology/*pharmacology[MESH] |Antibodies, Viral/immunology/pharmacology[MESH] |Antigens, Viral/immunology[MESH] |COVID-19[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/*immunology/pathology/virology[MESH] |Epitopes/immunology[MESH] |Humans[MESH] |Immunity, Cellular/immunology[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*genetics/immunology[MESH] |Pneumonia, Viral/*immunology/pathology/virology[MESH] |Spike Glycoprotein, Coronavirus/antagonists & inhibitors/*immunology[MESH] |T-Lymphocytes, Helper-Inducer/immunology[MESH]Humoral and circulating follicular helper T cell responses in recovere(epmc).pdf DeepDyve Pubget Overpricing