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10.1038/s41392-020-00233-4 http://scihub22266oqcxt.onion/10.1038/s41392-020-00233-4 32661235!7356129!32661235     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Signal+Transduct+Target+Ther 2020 ; 5 (1): 125 Nephropedia Template TP {{tp|p=32661235|t=2020. Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development |pdf=|usr=}}{{32661235}} gab.com Text Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development JO: Signal Transduct Target Ther http://www.kidney.de/pget.php?&tw=1&pmid=32661235 #FOAvip Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER associated stress proteins are molecular chaperones essential for cellular homeostasis. The major functions of HSPs include chaperoning misfolded or unfolded polypeptides, protecting cells from toxic stress, and presenting immune and inflammatory cytokines. Regarded as a double-edged sword, HSPs also cooperate with numerous viruses and cancer cells to promote their survival. RNA chaperones are a group of heterogeneous nuclear ribonucleoproteins (hnRNPs), which are essential factors for manipulating both the functions and metabolisms of pre-mRNAs/hnRNAs transcribed by RNA polymerase II. hnRNPs involve in a large number of cellular processes, including chromatin remodelling, transcription regulation, RNP assembly and stabilization, RNA export, virus replication, histone-like nucleoid structuring, and even intracellular immunity. Dysregulation of stress proteins is associated with many human diseases including human cancer, cardiovascular diseases, neurodegenerative diseases (e.g., Parkinson's diseases, Alzheimer disease), stroke and infectious diseases. In this review, we summarized the biologic function of stress proteins, and current progress on their mechanisms related to virus reproduction and diseases caused by virus infections. As SPs also attract a great interest as potential antiviral targets (e.g., COVID-19), we also discuss the present progress and challenges in this area of HSP-based drug development, as well as with compounds already under clinical evaluation. Twit Text FOAVip Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development ????Signal Transduct Target Ther http://www.kidney.de/pget.php?&tw=1&pmid=32661235 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32661235 #FOAvip English Wikipedia <ref>{{Cite pmid|32661235}}</ref> Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development #MMPMID32661235 Wan Q; Song D; Li H; He ML Signal Transduct Target Ther 2020[Jul]; 5 (1): 125 PMID32661235show ga Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER associated stress proteins are molecular chaperones essential for cellular homeostasis. The major functions of HSPs include chaperoning misfolded or unfolded polypeptides, protecting cells from toxic stress, and presenting immune and inflammatory cytokines. Regarded as a double-edged sword, HSPs also cooperate with numerous viruses and cancer cells to promote their survival. RNA chaperones are a group of heterogeneous nuclear ribonucleoproteins (hnRNPs), which are essential factors for manipulating both the functions and metabolisms of pre-mRNAs/hnRNAs transcribed by RNA polymerase II. hnRNPs involve in a large number of cellular processes, including chromatin remodelling, transcription regulation, RNP assembly and stabilization, RNA export, virus replication, histone-like nucleoid structuring, and even intracellular immunity. Dysregulation of stress proteins is associated with many human diseases including human cancer, cardiovascular diseases, neurodegenerative diseases (e.g., Parkinson's diseases, Alzheimer disease), stroke and infectious diseases. In this review, we summarized the biologic function of stress proteins, and current progress on their mechanisms related to virus reproduction and diseases caused by virus infections. As SPs also attract a great interest as potential antiviral targets (e.g., COVID-19), we also discuss the present progress and challenges in this area of HSP-based drug development, as well as with compounds already under clinical evaluation. |Antiviral Agents/chemical synthesis/*pharmacology[MESH] |Betacoronavirus/*drug effects/genetics/pathogenicity[MESH] |COVID-19[MESH] |Chromatin Assembly and Disassembly/drug effects[MESH] |Coronavirus Infections/*drug therapy/genetics/pathology/virology[MESH] |Gene Expression Regulation[MESH] |Heat-Shock Proteins/agonists/antagonists & inhibitors/*genetics/metabolism[MESH] |Heterogeneous-Nuclear Ribonucleoproteins/agonists/antagonists & inhibitors/*genetics/metabolism[MESH] |Host-Pathogen Interactions/*drug effects/genetics[MESH] |Humans[MESH] |Molecular Targeted Therapy/methods[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/genetics/pathology/virology[MESH] |RNA Polymerase II/genetics/metabolism[MESH] |RNA Precursors/genetics/metabolism[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH] |Signal Transduction[MESH] |Transcription, Genetic/drug effects[MESH]Stress proteins: the biological functions in virus infection, present (epmc).pdf DeepDyve Pubget Overpricing