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10.1007/s12038-020-00067-w

http://scihub22266oqcxt.onion/10.1007/s12038-020-00067-w

32661214!7323606!32661214
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      J+Biosci 2020 ; 45 (1): ä
Nephropedia Template TP
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gab.com Text
Drug targets for COVID-19 therapeutics: Ongoing global efforts JO: J Biosci http://www.kidney.de/pget.php?&tw=1&pmid=32661214 #FOAvip The current global pandemic COVID-19 caused by the SARS-CoV-2 virus has already inflicted insurmountable damage both to the human lives and global economy. There is an immediate need for identification of effective drugs to contain the disastrous virus outbreak. Global efforts are already underway at a war footing to identify the best drug combination to address the disease. In this review, an attempt has been made to understand the SARS-CoV-2 life cycle, and based on this information potential druggable targets against SARS-CoV-2 are summarized. Also, the strategies for ongoing and future drug discovery against the SARSCoV- 2 virus are outlined. Given the urgency to find a definitive cure, ongoing drug repurposing efforts being carried out by various organizations are also described. The unprecedented crisis requires extraordinary efforts from the scientific community to effectively address the issue and prevent further loss of human lives and health.
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Drug targets for COVID-19 therapeutics: Ongoing global efforts ????J Biosci http://www.kidney.de/pget.php?&tw=1&pmid=32661214 #FOAvip
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<ref>{{Cite pmid|32661214}}</ref>

Drug targets for COVID-19 therapeutics: Ongoing global efforts #MMPMID32661214
Saxena A
J Biosci 2020[]; 45 (1): ä PMID32661214show ga
The current global pandemic COVID-19 caused by the SARS-CoV-2 virus has already inflicted insurmountable damage both to the human lives and global economy. There is an immediate need for identification of effective drugs to contain the disastrous virus outbreak. Global efforts are already underway at a war footing to identify the best drug combination to address the disease. In this review, an attempt has been made to understand the SARS-CoV-2 life cycle, and based on this information potential druggable targets against SARS-CoV-2 are summarized. Also, the strategies for ongoing and future drug discovery against the SARSCoV- 2 virus are outlined. Given the urgency to find a definitive cure, ongoing drug repurposing efforts being carried out by various organizations are also described. The unprecedented crisis requires extraordinary efforts from the scientific community to effectively address the issue and prevent further loss of human lives and health.
|*Drug Repositioning[MESH]
|*Pandemics[MESH]
|Adrenal Cortex Hormones/*therapeutic use[MESH]
|Angiotensin-Converting Enzyme 2[MESH]
|Antiviral Agents/*therapeutic use[MESH]
|Betacoronavirus/drug effects/immunology/pathogenicity[MESH]
|COVID-19[MESH]
|Coronavirus Infections/*drug therapy/epidemiology/immunology/virology[MESH]
|Disease Progression[MESH]
|Drug Discovery[MESH]
|Gene Expression Regulation[MESH]
|Host-Pathogen Interactions/drug effects/genetics/immunology[MESH]
|Humans[MESH]
|Hydroxychloroquine/therapeutic use[MESH]
|Immunologic Factors/*therapeutic use[MESH]
|Molecular Docking Simulation[MESH]
|Molecular Targeted Therapy/methods[MESH]
|Peptidyl-Dipeptidase A/genetics/immunology[MESH]
|Pneumonia, Viral/*drug therapy/epidemiology/immunology/virology[MESH]
|SARS-CoV-2[MESH]
|Signal Transduction/genetics/immunology[MESH]Drug targets for COVID-19 therapeutics: Ongoing global efforts (epmc).pdf

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