Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1126/science.abc6027 http://scihub22266oqcxt.onion/10.1126/science.abc6027 32661059!7402632!32661059     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32661059&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2020 ; 369 (6504): 718-724 Nephropedia Template TP {{tp|p=32661059|t=2020. Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients |pdf=|usr=}}{{32661059}} gab.com Text Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=32661059 #FOAvip Coronavirus disease 2019 (COVID-19) is characterized by distinct patterns of disease progression that suggest diverse host immune responses. We performed an integrated immune analysis on a cohort of 50 COVID-19 patients with various disease severity. A distinct phenotype was observed in severe and critical patients, consisting of a highly impaired interferon (IFN) type I response (characterized by no IFN-beta and low IFN-alpha production and activity), which was associated with a persistent blood viral load and an exacerbated inflammatory response. Inflammation was partially driven by the transcriptional factor nuclear factor-kappaB and characterized by increased tumor necrosis factor-alpha and interleukin-6 production and signaling. These data suggest that type I IFN deficiency in the blood could be a hallmark of severe COVID-19 and provide a rationale for combined therapeutic approaches. Twit Text FOAVip Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients ????Science http://www.kidney.de/pget.php?&tw=1&pmid=32661059 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32661059 #FOAvip English Wikipedia <ref>{{Cite pmid|32661059}}</ref> Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients #MMPMID32661059 Hadjadj J; Yatim N; Barnabei L; Corneau A; Boussier J; Smith N; Pere H; Charbit B; Bondet V; Chenevier-Gobeaux C; Breillat P; Carlier N; Gauzit R; Morbieu C; Pene F; Marin N; Roche N; Szwebel TA; Merkling SH; Treluyer JM; Veyer D; Mouthon L; Blanc C; Tharaux PL; Rozenberg F; Fischer A; Duffy D; Rieux-Laucat F; Kerneis S; Terrier B Science 2020[Aug]; 369 (6504): 718-724 PMID32661059show ga Coronavirus disease 2019 (COVID-19) is characterized by distinct patterns of disease progression that suggest diverse host immune responses. We performed an integrated immune analysis on a cohort of 50 COVID-19 patients with various disease severity. A distinct phenotype was observed in severe and critical patients, consisting of a highly impaired interferon (IFN) type I response (characterized by no IFN-beta and low IFN-alpha production and activity), which was associated with a persistent blood viral load and an exacerbated inflammatory response. Inflammation was partially driven by the transcriptional factor nuclear factor-kappaB and characterized by increased tumor necrosis factor-alpha and interleukin-6 production and signaling. These data suggest that type I IFN deficiency in the blood could be a hallmark of severe COVID-19 and provide a rationale for combined therapeutic approaches. |Adult[MESH] |Aged[MESH] |Betacoronavirus/*immunology/physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology/virology[MESH] |Critical Illness[MESH] |Cross-Sectional Studies[MESH] |Female[MESH] |Gene Expression Profiling[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Inflammation[MESH] |Interferon alpha-2/*metabolism[MESH] |Interferon-alpha/*metabolism[MESH] |Interferon-beta/*metabolism[MESH] |Interleukin-6/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |NF-kappa B/metabolism[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/virology[MESH] |SARS-CoV-2[MESH] |Signal Transduction[MESH] |T-Lymphocyte Subsets/immunology[MESH] |Tumor Necrosis Factor-alpha/metabolism[MESH]Impaired type I interferon activity and inflammatory responses in seve(epmc).pdf DeepDyve Pubget Overpricing