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10.1186/s13054-020-03121-z

http://scihub22266oqcxt.onion/10.1186/s13054-020-03121-z
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32660520!7356133!32660520
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suck abstract from ncbi


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pmid32660520      Crit+Care 2020 ; 24 (1): 421
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  • Neurological manifestations of COVID-19: a systematic review #MMPMID32660520
  • Nepal G; Rehrig JH; Shrestha GS; Shing YK; Yadav JK; Ojha R; Pokhrel G; Tu ZL; Huang DY
  • Crit Care 2020[Jul]; 24 (1): 421 PMID32660520show ga
  • INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global spread of coronavirus disease (COVID-19). Our understanding of the impact this virus has on the nervous system is limited. Our review aims to inform and improve decision-making among the physicians treating COVID-19 by presenting a systematic analysis of the neurological manifestations experienced within these patients. METHODS: Any study, released prior to May 20, 2020, that reported neurological manifestations in patients infected by SARS-CoV-2 was systematically reviewed using the PRISMA (Preferred Reporting Items for Systemic review and Meta-Analysis) statement. RESULTS: Our systematic review included data from 37 articles: twelve retrospective studies, two prospective studies, and the rest case reports/series. The most commonly reported neurological manifestations of COVID-19 were myalgia, headache, altered sensorium, hyposmia, and hypogeusia. Uncommonly, COVID-19 can also present with central nervous system manifestations such as ischemic stroke, intracerebral hemorrhage, encephalo-myelitis, and acute myelitis, peripheral nervous manifestations such as Guillain-Barre syndrome and Bell's palsy, and skeletal muscle manifestations such as rhabdomyolysis. CONCLUSION: While COVID-19 typically presents as a self-limiting respiratory disease, it has been reported in up to 20% of patients to progress to severe illness with multi-organ involvement. The neurological manifestations of COVID-19 are not uncommon, but our study found most resolve with treatment of the underlying infection. Although the timeliness of this review engages current challenges posed by the COVID-19 pandemic, readers must not ignore the limitations and biases intrinsic to an early investigation.
  • |COVID-19[MESH]
  • |Coronavirus Infections/*complications[MESH]
  • |Humans[MESH]
  • |Nervous System Diseases/*virology[MESH]
  • |Pandemics[MESH]


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