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10.2174/1566524020666200713175426 http://scihub22266oqcxt.onion/10.2174/1566524020666200713175426 32660402!ä!32660402 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32660402&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Mol+Med 2021 ; 21 (1): 2-4 Nephropedia Template TP {{tp|p=32660402|t=2021. NPC1 as a Modulator of Disease Severity and Viral Entry of SARSCoV- 2 |pdf=|usr=}}{{32660402}} gab.com Text NPC1 as a Modulator of Disease Severity and Viral Entry of SARSCoV- 2 JO: Curr Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=32660402 #FOAvip The COVID-19 plague is hitting mankind. Several viruses, including SARS-CoV-1, MERS-CoV, EBOV, and SARS-CoV-2, use the endocytic machinery to enter the cell. Genomic variants in NPC1, which encodes for the endo-lysosomal Niemann-Pick type C1 protein, restricts the host-range of viruses in bats and susceptibility to infections in humans. Lack of NPC1 and its pharmacological suppression inhibits many viral infections including SARS-CoV-1 and Type I Feline Coronavirus Infection. Antiviral effects of NPC1-inhibiting drugs for COVID-19 treatment should be explored. Twit Text FOAVip NPC1 as a Modulator of Disease Severity and Viral Entry of SARSCoV- 2 ????Curr Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=32660402 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32660402 #FOAvip English Wikipedia <ref>{{Cite pmid|32660402}}</ref> NPC1 as a Modulator of Disease Severity and Viral Entry of SARSCoV- 2 #MMPMID32660402 Vial C; Calderon JF; Klein AD Curr Mol Med 2021[]; 21 (1): 2-4 PMID32660402show ga The COVID-19 plague is hitting mankind. Several viruses, including SARS-CoV-1, MERS-CoV, EBOV, and SARS-CoV-2, use the endocytic machinery to enter the cell. Genomic variants in NPC1, which encodes for the endo-lysosomal Niemann-Pick type C1 protein, restricts the host-range of viruses in bats and susceptibility to infections in humans. Lack of NPC1 and its pharmacological suppression inhibits many viral infections including SARS-CoV-1 and Type I Feline Coronavirus Infection. Antiviral effects of NPC1-inhibiting drugs for COVID-19 treatment should be explored. |Antiviral Agents/therapeutic use[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*physiopathology/virology[MESH] |Drug Repositioning[MESH] |Humans[MESH] |Intracellular Signaling Peptides and Proteins/*physiology[MESH] |Niemann-Pick C1 Protein[MESH] |SARS-CoV-2/*physiology[MESH] |Severity of Illness Index[MESH]NPC1 as a Modulator of Disease Severity and Viral Entry of SARSCoV- 2 (epmc).pdf DeepDyve Pubget Overpricing