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10.1177/2472555220942123 http://scihub22266oqcxt.onion/10.1177/2472555220942123 32660307!7684788!32660307     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       SLAS+Discov 2020 ; 25 (10): 1141-1151 Nephropedia Template TP {{tp|p=32660307|t=2020. RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery |pdf=|usr=}}{{32660307}} gab.com Text RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery JO: SLAS Discov http://www.kidney.de/pget.php?&tw=1&pmid=32660307 #FOAvip COVID-19 respiratory disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has rapidly become a global health issue since it emerged in December 2019. While great global efforts are underway to develop vaccines and to discover or repurpose therapeutic agents for this disease, as of this writing only the nucleoside drug remdesivir has been approved under Emergency Use Authorization to treat COVID-19. The RNA-dependent RNA polymerase (RdRP), a viral enzyme for viral RNA replication in host cells, is one of the most intriguing and promising drug targets for SARS-CoV-2 drug development. Because RdRP is a viral enzyme with no host cell homologs, selective SARS-CoV-2 RdRP inhibitors can be developed that have improved potency and fewer off-target effects against human host proteins and thus are safer and more effective therapeutics for treating COVID-19. This review focuses on biochemical enzyme and cell-based assays for RdRPs that could be used in high-throughput screening to discover new and repurposed drugs against SARS-CoV-2. Twit Text FOAVip RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery ????SLAS Discov http://www.kidney.de/pget.php?&tw=1&pmid=32660307 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32660307 #FOAvip English Wikipedia <ref>{{Cite pmid|32660307}}</ref> RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery #MMPMID32660307 Zhu W; Chen CZ; Gorshkov K; Xu M; Lo DC; Zheng W SLAS Discov 2020[Dec]; 25 (10): 1141-1151 PMID32660307show ga COVID-19 respiratory disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has rapidly become a global health issue since it emerged in December 2019. While great global efforts are underway to develop vaccines and to discover or repurpose therapeutic agents for this disease, as of this writing only the nucleoside drug remdesivir has been approved under Emergency Use Authorization to treat COVID-19. The RNA-dependent RNA polymerase (RdRP), a viral enzyme for viral RNA replication in host cells, is one of the most intriguing and promising drug targets for SARS-CoV-2 drug development. Because RdRP is a viral enzyme with no host cell homologs, selective SARS-CoV-2 RdRP inhibitors can be developed that have improved potency and fewer off-target effects against human host proteins and thus are safer and more effective therapeutics for treating COVID-19. This review focuses on biochemical enzyme and cell-based assays for RdRPs that could be used in high-throughput screening to discover new and repurposed drugs against SARS-CoV-2. |*COVID-19 Drug Treatment[MESH] |Adenosine Monophosphate/analogs & derivatives/chemistry/pharmacology[MESH] |Alanine/analogs & derivatives/chemistry/pharmacology[MESH] |Amides/chemistry/pharmacology[MESH] |Antiviral Agents/chemistry/*pharmacology[MESH] |Drug Discovery[MESH] |Enzyme Inhibitors/chemistry/*pharmacology[MESH] |High-Throughput Screening Assays/methods[MESH] |Humans[MESH] |Middle East Respiratory Syndrome Coronavirus/chemistry/drug effects[MESH] |Pyrazines/chemistry/pharmacology[MESH] |RNA-Dependent RNA Polymerase/*antagonists & inhibitors/chemistry/metabolism[MESH] |SARS-CoV-2/chemistry/drug effects[MESH] |Viral Proteins/*antagonists & inhibitors/chemistry/metabolism[MESH]RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery (epmc).pdf DeepDyve Pubget Overpricing