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10.3390/cells9071644 http://scihub22266oqcxt.onion/10.3390/cells9071644 32659887!7407487!32659887     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2020 ; 9 (7): ä Nephropedia Template TP {{tp|p=32659887|t=2020. Calcium-Sensing Receptor and Regulation of WNK Kinases in the Kidney |pdf=|usr=}}{{32659887}} gab.com Text Calcium-Sensing Receptor and Regulation of WNK Kinases in the Kidney JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=32659887 #FOAvip The kidney is essential for systemic calcium homeostasis. Urinary calcium excretion can be viewed as an integrative renal response to endocrine and local stimuli. The extracellular calcium-sensing receptor (CaSR) elicits a number of adaptive reactions to increased plasma Ca(2+) levels including the control of parathyroid hormone release and regulation of the renal calcium handling. Calcium reabsorption in the distal nephron of the kidney is functionally coupled to sodium transport. Apart from Ca(2+) transport systems, CaSR signaling affects relevant distal Na(+)-(K(+))-2Cl(-) cotransporters, NKCC2 and NCC. NKCC2 and NCC are activated by a kinase cascade comprising with-no-lysine [K] kinases (WNKs) and two homologous Ste20-related kinases, SPAK and OSR1. Gain-of-function mutations within the WNK-SPAK/OSR1-NKCC2/NCC pathway lead to renal salt retention and hypertension, whereas loss-of-function mutations have been associated with salt-losing tubulopathies such as Bartter or Gitelman syndromes. A Bartter-like syndrome has been also described in patients carrying gain-of-function mutations in the CaSR gene. Recent work suggested that CaSR signals via the WNK-SPAK/OSR1 cascade to modulate salt reabsorption along the distal nephron. The review presented here summarizes the latest progress in understanding of functional interactions between CaSR and WNKs and their potential impact on the renal salt handling and blood pressure. Twit Text FOAVip Calcium-Sensing Receptor and Regulation of WNK Kinases in the Kidney ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=32659887 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32659887 #FOAvip English Wikipedia <ref>{{Cite pmid|32659887}}</ref> Calcium-Sensing Receptor and Regulation of WNK Kinases in the Kidney #MMPMID32659887 Ostroverkhova DS; Hu J; Tarasov VV; Melnikova TI; Porozov YB; Mutig K Cells 2020[Jul]; 9 (7): ä PMID32659887show ga The kidney is essential for systemic calcium homeostasis. Urinary calcium excretion can be viewed as an integrative renal response to endocrine and local stimuli. The extracellular calcium-sensing receptor (CaSR) elicits a number of adaptive reactions to increased plasma Ca(2+) levels including the control of parathyroid hormone release and regulation of the renal calcium handling. Calcium reabsorption in the distal nephron of the kidney is functionally coupled to sodium transport. Apart from Ca(2+) transport systems, CaSR signaling affects relevant distal Na(+)-(K(+))-2Cl(-) cotransporters, NKCC2 and NCC. NKCC2 and NCC are activated by a kinase cascade comprising with-no-lysine [K] kinases (WNKs) and two homologous Ste20-related kinases, SPAK and OSR1. Gain-of-function mutations within the WNK-SPAK/OSR1-NKCC2/NCC pathway lead to renal salt retention and hypertension, whereas loss-of-function mutations have been associated with salt-losing tubulopathies such as Bartter or Gitelman syndromes. A Bartter-like syndrome has been also described in patients carrying gain-of-function mutations in the CaSR gene. Recent work suggested that CaSR signals via the WNK-SPAK/OSR1 cascade to modulate salt reabsorption along the distal nephron. The review presented here summarizes the latest progress in understanding of functional interactions between CaSR and WNKs and their potential impact on the renal salt handling and blood pressure. |Animals[MESH] |Humans[MESH] |Kidney/cytology/*enzymology/*metabolism[MESH] |Nephrons/cytology/enzymology/metabolism[MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism[MESH] |Receptors, Calcium-Sensing/genetics/*metabolism[MESH]Calcium-Sensing Receptor and Regulation of WNK Kinases in the Kidney (epmc).pdf DeepDyve Pubget Overpricing