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10.1016/j.ajic.2020.07.011

http://scihub22266oqcxt.onion/10.1016/j.ajic.2020.07.011
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32659413!7350782!32659413
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suck abstract from ncbi


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pmid32659413      Am+J+Infect+Control 2021 ; 49 (1): 21-29
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  • Systematic review with meta-analysis of the accuracy of diagnostic tests for COVID-19 #MMPMID32659413
  • Boger B; Fachi MM; Vilhena RO; Cobre AF; Tonin FS; Pontarolo R
  • Am J Infect Control 2021[Jan]; 49 (1): 21-29 PMID32659413show ga
  • OBJECTIVE: To collate the evidence on the accuracy parameters of all available diagnostic methods for detecting SARS-CoV-2. METHODS: A systematic review with meta-analysis was performed. Searches were conducted in Pubmed and Scopus (April 2020). Studies reporting data on sensitivity or specificity of diagnostic tests for COVID-19 using any human biological sample were included. RESULTS: Sixteen studies were evaluated. Meta-analysis showed that computed tomography has high sensitivity (91.9% [89.8%-93.7%]), but low specificity (25.1% [21.0%-29.5%]). The combination of IgM and IgG antibodies demonstrated promising results for both parameters (84.5% [82.2%-86.6%]; 91.6% [86.0%-95.4%], respectively). For RT-PCR tests, rectal stools/swab, urine, and plasma were less sensitive while sputum (97.2% [90.3%-99.7%]) presented higher sensitivity for detecting the virus. CONCLUSIONS: RT-PCR remains the gold standard for the diagnosis of COVID-19 in sputum samples. However, the combination of different diagnostic tests is highly recommended to achieve adequate sensitivity and specificity.
  • |*COVID-19 Nucleic Acid Testing[MESH]
  • |*COVID-19 Serological Testing[MESH]
  • |Antibodies, Viral/immunology[MESH]
  • |COVID-19 Testing[MESH]
  • |COVID-19/*diagnosis/immunology[MESH]
  • |Coronavirus Envelope Proteins/genetics[MESH]
  • |Coronavirus RNA-Dependent RNA Polymerase/genetics[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/immunology[MESH]
  • |Immunoglobulin M/immunology[MESH]
  • |Lung/*diagnostic imaging[MESH]
  • |SARS-CoV-2/genetics/immunology[MESH]
  • |Sensitivity and Specificity[MESH]


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