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10.1016/j.jclinepi.2020.07.001 http://scihub22266oqcxt.onion/10.1016/j.jclinepi.2020.07.001 32659363!7351066!32659363     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Epidemiol 2020 ; 126 (ä): 167-171 Nephropedia Template TP {{tp|p=32659363|t=2020. Achieving effective informed oversight by DMCs in COVID clinical trials |pdf=|usr=}}{{32659363}} gab.com Text Achieving effective informed oversight by DMCs in COVID clinical trials JO: J Clin Epidemiol http://www.kidney.de/pget.php?&tw=1&pmid=32659363 #FOAvip Best practices of data monitoring committees (DMCs) in randomized clinical trials are well established. Independent oversight provided by DMCs is particularly important in trials conducted in public health emergencies, such as in HIV/AIDS or coronavirus epidemics. Special considerations are needed to enable DMCs to effectively address novel circumstances they face in such settings. In the COVID-19 pandemic, these include the remarkable speed in which data regarding benefits and risks of interventions are accumulated. DMCs must hold frequent virtual meetings, using state-of-the-art communication software that protects against risk for security breaches. Data capture and DMC reports should be focused on the most informative measures about benefits and risks. Because numerous clinical trials are being concurrently conducted in the COVID-19 setting, often addressing closely related scientific questions, structures for DMC oversight should be efficient and adequately informative. When these concurrently conducted trials are evaluating related regimens in related clinical settings, often individually underpowered for safety and having separate DMCs, processes should be implemented enabling these DMCs to share with each other emerging confidential evidence to better assess risks and benefits. Ideally a single DMC would monitor a portfolio of clinical trials or a trial with multiple arms, such as a platform trial. Twit Text FOAVip Achieving effective informed oversight by DMCs in COVID clinical trials ????J Clin Epidemiol http://www.kidney.de/pget.php?&tw=1&pmid=32659363 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32659363 #FOAvip English Wikipedia <ref>{{Cite pmid|32659363}}</ref> Achieving effective informed oversight by DMCs in COVID clinical trials #MMPMID32659363 DeMets DL; Fleming TR J Clin Epidemiol 2020[Oct]; 126 (ä): 167-171 PMID32659363show ga Best practices of data monitoring committees (DMCs) in randomized clinical trials are well established. Independent oversight provided by DMCs is particularly important in trials conducted in public health emergencies, such as in HIV/AIDS or coronavirus epidemics. Special considerations are needed to enable DMCs to effectively address novel circumstances they face in such settings. In the COVID-19 pandemic, these include the remarkable speed in which data regarding benefits and risks of interventions are accumulated. DMCs must hold frequent virtual meetings, using state-of-the-art communication software that protects against risk for security breaches. Data capture and DMC reports should be focused on the most informative measures about benefits and risks. Because numerous clinical trials are being concurrently conducted in the COVID-19 setting, often addressing closely related scientific questions, structures for DMC oversight should be efficient and adequately informative. When these concurrently conducted trials are evaluating related regimens in related clinical settings, often individually underpowered for safety and having separate DMCs, processes should be implemented enabling these DMCs to share with each other emerging confidential evidence to better assess risks and benefits. Ideally a single DMC would monitor a portfolio of clinical trials or a trial with multiple arms, such as a platform trial. |*Betacoronavirus[MESH] |*Clinical Trials Data Monitoring Committees[MESH] |*Research Design[MESH] |COVID-19[MESH] |Clinical Trials as Topic/*methods[MESH] |Coronavirus Infections/prevention & control/*therapy[MESH] |Humans[MESH] |Pandemics/prevention & control[MESH] |Pneumonia, Viral/prevention & control/*therapy[MESH]Achieving effective informed oversight by DMCs in COVID clinical trial(epmc).pdf DeepDyve Pubget Overpricing