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10.1016/j.pharmthera.2020.107627 http://scihub22266oqcxt.onion/10.1016/j.pharmthera.2020.107627 32659304!7351663!32659304     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pharmacol+Ther 2020 ; 215 (ä): 107627 Nephropedia Template TP {{tp|p=32659304|t=2020. Inflammation is a major regulator of drug metabolizing enzymes and transporters: Consequences for the personalization of drug treatment |pdf=|usr=}}{{32659304}} gab.com Text Inflammation is a major regulator of drug metabolizing enzymes and transporters: Consequences for the personalization of drug treatment JO: Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=32659304 #FOAvip Inflammation is an evolutionary process that allows survival against acute infection or injury. Inflammation is also a pathophysiological condition shared by numerous chronic diseases. In addition, inflammation modulates important drug-metabolizing enzymes and transporters (DMETs), thus contributing to intra- and interindividual variability of drug exposure. A better knowledge of the impact of inflammation on drug metabolism and its related clinical consequences would help to personalize drug treatment. Here, we summarize the kinetics of inflammatory mediators and the underlying transcriptional and post-transcriptional mechanisms by which they contribute to the inhibition of important DMETs. We also present an updated overview of the effect of inflammation on the pharmacokinetic parameters of most of the drugs that are DMET substrates, for which therapeutic drug monitoring is recommended. Furthermore, we provide opinions on how to integrate the inflammatory status into pharmacogenetics, therapeutic drug monitoring, and population pharmacokinetic strategies to improve the personalization of drug treatment for each patient. Twit Text FOAVip Inflammation is a major regulator of drug metabolizing enzymes and transporters: Consequences for the personalization of drug treatment ????Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=32659304 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32659304 #FOAvip English Wikipedia <ref>{{Cite pmid|32659304}}</ref> Inflammation is a major regulator of drug metabolizing enzymes and transporters: Consequences for the personalization of drug treatment #MMPMID32659304 Stanke-Labesque F; Gautier-Veyret E; Chhun S; Guilhaumou R Pharmacol Ther 2020[Nov]; 215 (ä): 107627 PMID32659304show ga Inflammation is an evolutionary process that allows survival against acute infection or injury. Inflammation is also a pathophysiological condition shared by numerous chronic diseases. In addition, inflammation modulates important drug-metabolizing enzymes and transporters (DMETs), thus contributing to intra- and interindividual variability of drug exposure. A better knowledge of the impact of inflammation on drug metabolism and its related clinical consequences would help to personalize drug treatment. Here, we summarize the kinetics of inflammatory mediators and the underlying transcriptional and post-transcriptional mechanisms by which they contribute to the inhibition of important DMETs. We also present an updated overview of the effect of inflammation on the pharmacokinetic parameters of most of the drugs that are DMET substrates, for which therapeutic drug monitoring is recommended. Furthermore, we provide opinions on how to integrate the inflammatory status into pharmacogenetics, therapeutic drug monitoring, and population pharmacokinetic strategies to improve the personalization of drug treatment for each patient. |Animals[MESH] |Drug Monitoring[MESH] |Humans[MESH] |Inflammation Mediators/metabolism[MESH] |Inflammation/*physiopathology[MESH] |Membrane Transport Proteins/*metabolism[MESH] |Pharmaceutical Preparations/*metabolism[MESH] |Pharmacogenetics[MESH]Inflammation is a major regulator of drug metabolizing enzymes and tra(epmc).pdf DeepDyve Pubget Overpricing