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10.1080/07315724.2020.1789518

http://scihub22266oqcxt.onion/10.1080/07315724.2020.1789518
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suck abstract from ncbi


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pmid32659175      J+Am+Coll+Nutr 2020 ; 39 (8): 694-699
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  • Can Vitamin D and L-Cysteine Co-Supplementation Reduce 25(OH)-Vitamin D Deficiency and the Mortality Associated with COVID-19 in African Americans? #MMPMID32659175
  • Jain SK; Parsanathan R
  • J Am Coll Nutr 2020[Nov]; 39 (8): 694-699 PMID32659175show ga
  • Early reports indicate an association between the severity of the COVID-19 infection and the widespread 25-hydroxy vitamin D deficiency known to exist in populations around the world. Vitamin D deficiency is extremely common among African American (AA) communities, where the COVID-19 infection rate is three-fold higher, and the mortality rate nearly six-fold higher, compared with rates in predominantly white communities. COVID-19 infection primarily affects the lungs and airways. Previous reports have linked 25-hydroxy vitamin D deficiency with subclinical interstitial lung disease. AA are at risk for lower cellular glutathione (GSH) levels, and GSH deficiency epigenetically impairs VD biosynthesis pathway genes. Compared with vitamin D alone, co-supplementation of vitamin D and L-cysteine (a GSH precursor) showed a better efficacy in improving levels of GSH and VD-regulatory genes at the cellular/tissue level, increasing 25(OH) vitamin D levels, and reducing inflammation biomarkers in the blood in mice studies. We propose that randomized clinical trials are needed to examine the potential of co-supplementation with anti-inflammatory antioxidants, vitamin D and L-cysteine in correcting the 25(OH)VD deficiency and preventing the 'cytokine storm,' one of the most severe consequences of infection with COVID-19, thereby preventing the adverse clinical effects of COVID-19 infection in the vulnerable AA population.
  • |*Black or African American[MESH]
  • |*COVID-19 Drug Treatment[MESH]
  • |*Dietary Supplements[MESH]
  • |Animals[MESH]
  • |Anti-Inflammatory Agents/pharmacology/therapeutic use[MESH]
  • |Antioxidants/pharmacology/therapeutic use[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19/ethnology/metabolism/mortality[MESH]
  • |Cysteine/pharmacology/*therapeutic use[MESH]
  • |Cytokines/metabolism[MESH]
  • |Epigenesis, Genetic[MESH]
  • |Genetic Predisposition to Disease[MESH]
  • |Glutathione/*metabolism[MESH]
  • |Humans[MESH]
  • |Inflammation/etiology/metabolism/prevention & control[MESH]
  • |Mice[MESH]
  • |Vitamin D Deficiency/*drug therapy/ethnology/metabolism[MESH]
  • |Vitamin D/analogs & derivatives/blood/pharmacology/*therapeutic use[MESH]


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