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10.1016/j.marpolbul.2020.111375

http://scihub22266oqcxt.onion/10.1016/j.marpolbul.2020.111375
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suck abstract from ncbi


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pmid32658716      Mar+Pollut+Bull 2020 ; 157 (ä): 111375
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  • Ecotoxic response of nematodes to ivermectin, a potential anti-COVID-19 drug treatment #MMPMID32658716
  • Essid N; Allouche M; Lazzem M; Harrath AH; Mansour L; Alwasel S; Mahmoudi E; Beyrem H; Boufahja F
  • Mar Pollut Bull 2020[Aug]; 157 (ä): 111375 PMID32658716show ga
  • At the end of March 2020, ivermectin was confirmed as a drug for COVID-19 treatment. A significant amount of ivermectin could deposit into sediments of the semi-closed Mediterranean Sea, where three European COVID-19 epicenters are located: Italy, Spain, and France. Meiobenthic nematodes were exposed to three ivermectin doses (1.8 ng.g(-1), 9 ng.g(-1), and 18 ng.g(-1)) for 10 days. Ivermectin caused a great reduction in abundance. However, the diversity indices decreased only at high doses. Ivermectin disadvantaged the 1B-Cr-Id functional type (non-selective deposit feeders and nematodes with circular or indistinct amphids) and benefited the 2A-REL-Sp type (epistrate feeders and nematodes with rounded or elongated loop amphids). Thus, Trophic Diversity and Amphideal Diversity index values increased with sedimentary ivermectin enrichment. Large amphideal foveas were more efficient for 2A-REL-Sp nematodes to avoid ivermectin. The responses of the functional type 2A-REL-Sp and corresponding taxa predict post-COVID-19 environmental concerns and the bioaccumulation of ivermectin in seafoods.
  • |*Coronavirus Infections/drug therapy[MESH]
  • |*Ivermectin/toxicity[MESH]
  • |*Nematoda[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/*toxicity[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |France[MESH]
  • |Humans[MESH]
  • |Italy[MESH]
  • |Mediterranean Sea[MESH]
  • |SARS-CoV-2[MESH]


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