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10.1002/prp2.623

http://scihub22266oqcxt.onion/10.1002/prp2.623
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32658389!7357286!32658389
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suck abstract from ncbi


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pmid32658389      Pharmacol+Res+Perspect 2020 ; 8 (4): e00623
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  • The renin-angiotensin-aldosterone system: Role in pathogenesis and potential therapeutic target in COVID-19 #MMPMID32658389
  • Braga CL; Silva-Aguiar RP; Battaglini D; Peruchetti DB; Robba C; Pelosi P; Rocco PRM; Caruso-Neves C; Silva PL
  • Pharmacol Res Perspect 2020[Aug]; 8 (4): e00623 PMID32658389show ga
  • Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 novel coronavirus, has spread worldwide causing high fatality rates. Neither a vaccine nor specific therapeutic approaches are available, hindering the fight against this disease and making better understanding of its pathogenesis essential. Despite similarities between SARS-CoV-2 and SARS-CoV, the former has unique characteristics which represent a great challenge to physicians. The mechanism of COVID-19 infection and pathogenesis is still poorly understood. In the present review, we highlight possible pathways involved in the pathogenesis of COVID-19 and potential therapeutic targets, focusing on the role of the renin-angiotensin-aldosterone system.
  • |*Renin-Angiotensin System/drug effects[MESH]
  • |Angiotensin Receptor Antagonists/therapeutic use[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Angiotensin-Converting Enzyme Inhibitors/therapeutic use[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Betacoronavirus/drug effects/*pathogenicity[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/diagnosis/drug therapy/*virology[MESH]
  • |Evidence-Based Medicine[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Peptidyl-Dipeptidase A/*metabolism/therapeutic use[MESH]
  • |Pneumonia, Viral/diagnosis/drug therapy/*virology[MESH]


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