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10.1002/jcla.23467

http://scihub22266oqcxt.onion/10.1002/jcla.23467
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suck abstract from ncbi


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pmid32656888      J+Clin+Lab+Anal 2020 ; 34 (10): e23467
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  • Laboratory abnormalities and risk factors associated with in-hospital death in patients with severe COVID-19 #MMPMID32656888
  • Chen X; Yan L; Fei Y; Zhang C
  • J Clin Lab Anal 2020[Oct]; 34 (10): e23467 PMID32656888show ga
  • BACKGROUND: In the context of the COVID-19 outbreak of worldwide, we aim to analyze the laboratory risk factors of in-hospital death in patients with severe COVID-19. METHODS: All >/=18-year-old patients with confirmed severe COVID-19 admitted to Tongji Hospital (Wuhan, China) from February 3 to February 20, 2020, were retrospectively enrolled and followed up until March 20, 2020. Epidemiological, clinical, laboratory, and treatment data were collected and explored the risk factors associated with in-hospital death. RESULTS: A total of 73 severe patients were enrolled in the study, of whom 20 (27%) patients died in hospital during the average 28 days of follow-up period. The median age of non-survivors was significantly older than survivors (69 [64-76.5] years vs 64 [56-71.3] years, P = .033) and 15 (75%) patients were males. The laboratory abnormalities of non-survivors mainly presented in serious inflammation response and multiple organ failure, with high levels of cytokines and deranged coagulation parameters. Multivariable regression showed that neutrophil count greater than 4.47 x 10(9) /L (OR, 58.35; 95%CI: 2.16-1571.69; P = .016), hypersensitivity C-reactive protein greater than 86.7 mg/L (OR, 14.90; 95%CI: 1.29-171.10; P = .030), creatine kinase greater than 101 U/L (OR, 161.62; 95%CI: 6.45-4045.20; P = .002), and blood urea nitrogen greater than 6.7 mmol/L (OR, 11.18; 95%CI: 1.36-91.62; P = .024) were risk factors for in-hospital death. CONCLUSION: The risk factors of neutrophil count, hypersensitivity C-reactive protein, creatine kinase, and blood urea nitrogen could help clinicians to early identify COVID-19 severe patients with poor outcomes on admission. Virus direct attack and cytokine storm play a major role in the death of COVID-19.
  • |*Coronavirus Infections/diagnosis/epidemiology/mortality/therapy[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/diagnosis/epidemiology/mortality/therapy[MESH]
  • |Aged[MESH]
  • |Betacoronavirus[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |China[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Creatine Kinase/blood[MESH]
  • |Critical Illness[MESH]
  • |Cytokine Release Syndrome[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Leukocyte Count[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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