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10.4110/in.2020.20.e20

http://scihub22266oqcxt.onion/10.4110/in.2020.20.e20
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suck abstract from ncbi


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pmid32655968      Immune+Netw 2020 ; 20 (3): e20
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  • The Roles of CCR7 for the Homing of Memory CD8+ T Cells into Their Survival Niches #MMPMID32655968
  • Choi H; Song H; Jung YW
  • Immune Netw 2020[Jun]; 20 (3): e20 PMID32655968show ga
  • Memory CD8+ T cells in the immune system are responsible for the removal of external Ags for a long period of time to protect against re-infection. Naive to memory CD8+ T cell differentiation and memory CD8+ T cell maintenance require many different factors including local environmental factors. Thus, it has been suggested that the migration of memory CD8+ T cells into specific microenvironments alters their longevity and functions. In this review, we have summarized the subsets of memory CD8+ T cells based on their migratory capacities and described the niche hypothesis for their survival. In addition, the basic roles of CCR7 in conjunction with the migration of memory CD8+ T cells and recent understandings of their survival niches have been introduced. Finally, the applications of altering CCR7 signaling have been discussed.
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