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10.3389/fimmu.2020.01512

http://scihub22266oqcxt.onion/10.3389/fimmu.2020.01512
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32655581!7324763!32655581
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suck abstract from ncbi


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pmid32655581      Front+Immunol 2020 ; 11 (ä): 1512
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  • Flattening the COVID-19 Curve With Natural Killer Cell Based Immunotherapies #MMPMID32655581
  • Market M; Angka L; Martel AB; Bastin D; Olanubi O; Tennakoon G; Boucher DM; Ng J; Ardolino M; Auer RC
  • Front Immunol 2020[]; 11 (ä): 1512 PMID32655581show ga
  • Natural Killer (NK) cells are innate immune responders critical for viral clearance and immunomodulation. Despite their vital role in viral infection, the contribution of NK cells in fighting SARS-CoV-2 has not yet been directly investigated. Insights into pathophysiology and therapeutic opportunities can therefore be inferred from studies assessing NK cell phenotype and function during SARS, MERS, and COVID-19. These studies suggest a reduction in circulating NK cell numbers and/or an exhausted phenotype following infection and hint toward the dampening of NK cell responses by coronaviruses. Reduced circulating NK cell levels and exhaustion may be directly responsible for the progression and severity of COVID-19. Conversely, in light of data linking inflammation with coronavirus disease severity, it is necessary to examine NK cell potential in mediating immunopathology. A common feature of coronavirus infections is that significant morbidity and mortality is associated with lung injury and acute respiratory distress syndrome resulting from an exaggerated immune response, of which NK cells are an important component. In this review, we summarize the current understanding of how NK cells respond in both early and late coronavirus infections, and the implication for ongoing COVID-19 clinical trials. Using this immunological lens, we outline recommendations for therapeutic strategies against COVID-19 in clearing the virus while preventing the harm of immunopathological responses.
  • |Adoptive Transfer/*methods[MESH]
  • |Adrenal Cortex Hormones/therapeutic use[MESH]
  • |Animals[MESH]
  • |Anti-Inflammatory Agents, Non-Steroidal/therapeutic use[MESH]
  • |Ascorbic Acid/therapeutic use[MESH]
  • |Betacoronavirus/drug effects/*immunology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy/*immunology/mortality/virology[MESH]
  • |Cytokines/antagonists & inhibitors/metabolism[MESH]
  • |Disease Susceptibility/immunology[MESH]
  • |Humans[MESH]
  • |Immunity, Innate/drug effects/immunology[MESH]
  • |Immunologic Memory[MESH]
  • |Interferon Type I/metabolism/therapeutic use[MESH]
  • |Killer Cells, Natural/drug effects/*immunology[MESH]
  • |Mice[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/*immunology/mortality/virology[MESH]


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  • suck abstract from ncbi

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