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10.3389/fimmu.2020.01439

http://scihub22266oqcxt.onion/10.3389/fimmu.2020.01439
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32655577!7324709!32655577
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suck abstract from ncbi


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pmid32655577      Front+Immunol 2020 ; 11 (ä): 1439
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  • Targeting the Immune System for Pulmonary Inflammation and Cardiovascular Complications in COVID-19 Patients #MMPMID32655577
  • Colafrancesco S; Scrivo R; Barbati C; Conti F; Priori R
  • Front Immunol 2020[]; 11 (ä): 1439 PMID32655577show ga
  • In December 2019, following a cluster of pneumonia cases in China caused by a novel coronavirus (CoV), named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the infection disseminated worldwide and, on March 11th, 2020, the World Health Organization officially declared the pandemic of the relevant disease named coronavirus disease 2019 (COVID-19). In Europe, Italy was the first country facing a true health policy emergency, and, as at 6.00 p.m. on May 2nd, 2020, there have been more than 209,300 confirmed cases of COVID-19. Due to the increasing number of patients experiencing a severe outcome, global scientific efforts are ongoing to find the most appropriate treatment. The usefulness of specific anti-rheumatic drugs came out as a promising treatment option together with antiviral drugs, anticoagulants, and symptomatic and respiratory support. For this reason, we feel a duty to share our experience and our knowledge on the use of these drugs in the immune-rheumatologic field, providing in this review the rationale for their use in the COVID-19 pandemic.
  • |Adaptive Immunity/drug effects[MESH]
  • |Adult[MESH]
  • |Anticoagulants/therapeutic use[MESH]
  • |Antirheumatic Agents/therapeutic use[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Betacoronavirus/immunology/*metabolism[MESH]
  • |COVID-19[MESH]
  • |Cardiovascular Diseases/*drug therapy/*etiology[MESH]
  • |Coronavirus Infections/*complications/*drug therapy/immunology/virology[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/therapeutic use[MESH]
  • |Immunity, Innate/drug effects[MESH]
  • |Interleukin-1/antagonists & inhibitors[MESH]
  • |Interleukin-6/antagonists & inhibitors[MESH]
  • |Janus Kinase Inhibitors/therapeutic use[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/*drug therapy/immunology/virology[MESH]
  • |Respiratory Distress Syndrome/drug therapy/etiology[MESH]


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