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10.3389/fimmu.2020.01062 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.01062 32655549!7324478!32655549     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 1062 Nephropedia Template TP {{tp|p=32655549|t=2020. Regulation of Human Innate Lymphoid Cells in the Context of Mucosal Inflammation |pdf=|usr=}}{{32655549}} gab.com Text Regulation of Human Innate Lymphoid Cells in the Context of Mucosal Inflammation JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32655549 #FOAvip Since their identification as a unique cell population, innate lymphoid cells (ILCs) have revolutionized our understanding of immune responses, leaving their impact on multiple inflammatory and fibrotic pathologies without doubt. Thus, a tightly controlled regulation of local ILC numbers and their activity is of crucial importance. Even though this has been extensively studied in murine ILCs in the last few years, our knowledge of human ILCs is still lagging behind. Our review article will therefore summarize recent insights into the function of human ILCs and will particularly focus on their regulation under inflammatory conditions. The quality and intensity of ILC involvement into local immune responses at mucosal sites of the human body can potentially be modulated via three different axes: (1) activation of tissue-resident mature ILCs, (2) plasticity and local transdifferentiation of specific ILC subsets, and (3) tissue migration and accumulation of peripheral ILCs. Despite a still ongoing scientific effort in this field, already existing data on the fate of human ILCs under different pathologic conditions clearly indicate that all three of these mechanisms are of relevance for the clinical course of chronic inflammatory and autoimmune diseases and might likewise provide new target structures for future therapeutic strategies. Twit Text FOAVip Regulation of Human Innate Lymphoid Cells in the Context of Mucosal Inflammation ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32655549 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32655549 #FOAvip English Wikipedia <ref>{{Cite pmid|32655549}}</ref> Regulation of Human Innate Lymphoid Cells in the Context of Mucosal Inflammation #MMPMID32655549 Schulz-Kuhnt A; Wirtz S; Neurath MF; Atreya I Front Immunol 2020[]; 11 (ä): 1062 PMID32655549show ga Since their identification as a unique cell population, innate lymphoid cells (ILCs) have revolutionized our understanding of immune responses, leaving their impact on multiple inflammatory and fibrotic pathologies without doubt. Thus, a tightly controlled regulation of local ILC numbers and their activity is of crucial importance. Even though this has been extensively studied in murine ILCs in the last few years, our knowledge of human ILCs is still lagging behind. Our review article will therefore summarize recent insights into the function of human ILCs and will particularly focus on their regulation under inflammatory conditions. The quality and intensity of ILC involvement into local immune responses at mucosal sites of the human body can potentially be modulated via three different axes: (1) activation of tissue-resident mature ILCs, (2) plasticity and local transdifferentiation of specific ILC subsets, and (3) tissue migration and accumulation of peripheral ILCs. Despite a still ongoing scientific effort in this field, already existing data on the fate of human ILCs under different pathologic conditions clearly indicate that all three of these mechanisms are of relevance for the clinical course of chronic inflammatory and autoimmune diseases and might likewise provide new target structures for future therapeutic strategies. |*Immunity, Innate[MESH] |*Immunity, Mucosal[MESH] |Cell Differentiation/immunology[MESH] |Cell Movement/immunology[MESH] |Cytokines/immunology[MESH] |Humans[MESH] |Immunomodulation[MESH] |Inflammation/*immunology/pathology[MESH] |Lymphocyte Subsets/immunology/pathology[MESH] |Lymphocytes/*immunology/pathology[MESH]Regulation of Human Innate Lymphoid Cells in the Context of Mucosal In(epmc).pdf DeepDyve Pubget Overpricing