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10.1016/j.jiph.2020.06.030 http://scihub22266oqcxt.onion/10.1016/j.jiph.2020.06.030 32654959!7328614!32654959     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Infect+Public+Health 2020 ; 13 (10): 1544-1550 Nephropedia Template TP {{tp|p=32654959|t=2020. Evolving sequence mutations in the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) |pdf=|usr=}}{{32654959}} gab.com Text Evolving sequence mutations in the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) JO: J Infect Public Health http://www.kidney.de/pget.php?&tw=1&pmid=32654959 #FOAvip BACKGROUND: Middle East respiratory syndrome coronavirus (MERS-CoV) has continued to cause sporadic outbreaks of severe respiratory tract infection over the last 8 years. METHODS: Complete genome sequencing using next-generation sequencing was performed for MERS-CoV isolates from cases that occurred in Riyadh between 2015 and 2019. Phylogenetic analysis and molecular mutational analysis were carried out to investigate disease severity. RESULTS: A total of eight MERS-CoV isolates were subjected to complete genome sequencing. Phylogenetic analysis resulted in the assembly of 7/8 sequences within lineage 3 and one sequence within lineage 4 showing complex genomic recombination. The isolates contained a variety of unique amino acid substitutions in ORF1ab (41), the N protein (10), the S protein (9) and ORF4b (5). CONCLUSION: Our study shows that MERS-CoV is evolving. The emergence of new variants carries the potential for increased virulence and could impose a challenge to the global health system. We recommend the sequencing every new MERS-CoV isolate to observe the changes in the virus and relate them to clinical outcomes. Twit Text FOAVip Evolving sequence mutations in the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) ????J Infect Public Health http://www.kidney.de/pget.php?&tw=1&pmid=32654959 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32654959 #FOAvip English Wikipedia <ref>{{Cite pmid|32654959}}</ref> Evolving sequence mutations in the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) #MMPMID32654959 AlBalwi MA; Khan A; AlDrees M; Gk U; Manie B; Arabi Y; Alabdulkareem I; AlJohani S; Alghoribi M; AlAskar A; AlAjlan A; Hajeer A J Infect Public Health 2020[Oct]; 13 (10): 1544-1550 PMID32654959show ga BACKGROUND: Middle East respiratory syndrome coronavirus (MERS-CoV) has continued to cause sporadic outbreaks of severe respiratory tract infection over the last 8 years. METHODS: Complete genome sequencing using next-generation sequencing was performed for MERS-CoV isolates from cases that occurred in Riyadh between 2015 and 2019. Phylogenetic analysis and molecular mutational analysis were carried out to investigate disease severity. RESULTS: A total of eight MERS-CoV isolates were subjected to complete genome sequencing. Phylogenetic analysis resulted in the assembly of 7/8 sequences within lineage 3 and one sequence within lineage 4 showing complex genomic recombination. The isolates contained a variety of unique amino acid substitutions in ORF1ab (41), the N protein (10), the S protein (9) and ORF4b (5). CONCLUSION: Our study shows that MERS-CoV is evolving. The emergence of new variants carries the potential for increased virulence and could impose a challenge to the global health system. We recommend the sequencing every new MERS-CoV isolate to observe the changes in the virus and relate them to clinical outcomes. |*Mutation[MESH] |Adult[MESH] |Aged[MESH] |Amino Acids/genetics[MESH] |Coronavirus Infections/*virology[MESH] |Coronavirus Nucleocapsid Proteins[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Middle East Respiratory Syndrome Coronavirus/*genetics[MESH] |Nucleocapsid Proteins/genetics[MESH] |Phylogeny[MESH] |RNA, Viral/*analysis[MESH] |Saudi Arabia[MESH] |Virulence/genetics[MESH]Evolving sequence mutations in the Middle East Respiratory Syndrome Co(epmc).pdf DeepDyve Pubget Overpricing