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10.1016/j.bcp.2020.114147 http://scihub22266oqcxt.onion/10.1016/j.bcp.2020.114147 32653589!7347500!32653589     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Pharmacol 2020 ; 180 (ä): 114147 Nephropedia Template TP {{tp|p=32653589|t=2020. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective |pdf=|usr=}}{{32653589}} gab.com Text Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective JO: Biochem Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32653589 #FOAvip Owing to the efficacy in reducing pain and inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) are amongst the most popularly used medicines confirming their position in the WHO's Model List of Essential Medicines. With escalating musculoskeletal complications, as evident from 2016 Global Burden of Disease data, NSAID usage is evidently unavoidable. Apart from analgesic, anti-inflammatory and antipyretic efficacies, NSAIDs are further documented to offer protection against diverse critical disorders including cancer and heart attacks. However, data from multiple placebo-controlled trials and meta-analyses studies alarmingly signify the adverse effects of NSAIDs in gastrointestinal, cardiovascular, hepatic, renal, cerebral and pulmonary complications. Although extensive research has elucidated the mechanisms underlying the clinical hazards of NSAIDs, no review has extensively collated the outcomes on various multiorgan toxicities of these drugs together. In this regard, the present review provides a comprehensive insight of the existing knowledge and recent developments on NSAID-induced organ damage. It precisely encompasses the current understanding of structure, classification and mode of action of NSAIDs while reiterating on the emerging instances of NSAID drug repurposing along with pharmacophore modification aimed at safer usage of NSAIDs where toxic effects are tamed without compromising the clinical benefits. The review does not intend to vilify these 'wonder drugs'; rather provides a careful understanding of their side-effects which would be beneficial in evaluating the risk-benefit threshold while rationally using NSAIDs at safer dose and duration. Twit Text FOAVip Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective ????Biochem Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32653589 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32653589 #FOAvip English Wikipedia <ref>{{Cite pmid|32653589}}</ref> Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective #MMPMID32653589 Bindu S; Mazumder S; Bandyopadhyay U Biochem Pharmacol 2020[Oct]; 180 (ä): 114147 PMID32653589show ga Owing to the efficacy in reducing pain and inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) are amongst the most popularly used medicines confirming their position in the WHO's Model List of Essential Medicines. With escalating musculoskeletal complications, as evident from 2016 Global Burden of Disease data, NSAID usage is evidently unavoidable. Apart from analgesic, anti-inflammatory and antipyretic efficacies, NSAIDs are further documented to offer protection against diverse critical disorders including cancer and heart attacks. However, data from multiple placebo-controlled trials and meta-analyses studies alarmingly signify the adverse effects of NSAIDs in gastrointestinal, cardiovascular, hepatic, renal, cerebral and pulmonary complications. Although extensive research has elucidated the mechanisms underlying the clinical hazards of NSAIDs, no review has extensively collated the outcomes on various multiorgan toxicities of these drugs together. In this regard, the present review provides a comprehensive insight of the existing knowledge and recent developments on NSAID-induced organ damage. It precisely encompasses the current understanding of structure, classification and mode of action of NSAIDs while reiterating on the emerging instances of NSAID drug repurposing along with pharmacophore modification aimed at safer usage of NSAIDs where toxic effects are tamed without compromising the clinical benefits. The review does not intend to vilify these 'wonder drugs'; rather provides a careful understanding of their side-effects which would be beneficial in evaluating the risk-benefit threshold while rationally using NSAIDs at safer dose and duration. |Animals[MESH] |Anti-Inflammatory Agents, Non-Steroidal/*adverse effects/classification/*pharmacology[MESH] |Cyclooxygenase 2 Inhibitors/adverse effects/classification/pharmacology[MESH] |Humans[MESH] |Multiple Organ Failure/*chemically induced/metabolism[MESH] |Oxidative Stress/drug effects/physiology[MESH]Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A cur(epmc).pdf DeepDyve Pubget Overpricing