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10.1016/j.ajic.2020.07.005

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suck abstract from ncbi


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pmid32652252      Am+J+Infect+Control 2021 ; 49 (2): 158-165
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  • Clinical characteristics, outcomes and prognosticators in adult patients hospitalized with COVID-19 #MMPMID32652252
  • Gavin W; Campbell E; Zaidi SA; Gavin N; Dbeibo L; Beeler C; Kuebler K; Abdel-Rahman A; Luetkemeyer M; Kara A
  • Am J Infect Control 2021[Feb]; 49 (2): 158-165 PMID32652252show ga
  • BACKGROUND: COVID-19 is a novel disease caused by SARS-CoV-2. METHODS: We conducted a retrospective evaluation of patients admitted with COVID-19 to one site in March 2020. Patients were stratified into 3 groups: survivors who did not receive mechanical ventilation (MV), survivors who received MV, and those who received MV and died during hospitalization. RESULTS: There were 140 hospitalizations; 22 deaths (mortality rate 15.7%), 83 (59%) survived and did not receive MV, 35 (25%) received MV and survived; 18 (12.9%) received MV and died. Thee mean age of each group was 57.8, 55.8 and 72.7 years, respectively (P?=?.0001). Of those who received MV and died, 61% were male (P = .01). More than half the patients (n?=?90, 64%) were African American. First measured d-dimer >575.5 ng/mL, procalcitonin > 0.24 ng/mL, lactate dehydrogenase >445.6 units/L, and brain natriuretic peptide (BNP) >104.75 pg/mL had odds ratios of 10.5, 5, 4.5 and 2.9, respectively for MV (P < .05 for all). Peak BNP >167.5 pg/mL had an odds ratio of 6.7 for inpatient mortality when mechanically ventilated (P = .02). CONCLUSIONS: Age and gender may impact outcomes in COVID-19. D-dimer, procalcitonin, lactate dehydrogenase and BNP may serve as early indicators of disease trajectory.
  • |*SARS-CoV-2[MESH]
  • |Adult[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |COVID-19/blood/*mortality/therapy[MESH]
  • |Female[MESH]
  • |Fibrin Fibrinogen Degradation Products/analysis[MESH]
  • |Hospitalization/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |L-Lactate Dehydrogenase/blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Natriuretic Peptide, Brain/blood[MESH]
  • |Odds Ratio[MESH]
  • |Organ Dysfunction Scores[MESH]
  • |Procalcitonin/blood[MESH]
  • |Prognosis[MESH]
  • |Respiration, Artificial/*mortality[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]


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