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10.1016/j.jhin.2020.07.009

http://scihub22266oqcxt.onion/10.1016/j.jhin.2020.07.009
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32652214!7343644!32652214
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suck abstract from ncbi

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  • Factors affecting stability and infectivity of SARS-CoV-2 #MMPMID32652214
  • Chan KH; Sridhar S; Zhang RR; Chu H; Fung AY; Chan G; Chan JF; To KK; Hung IF; Cheng VC; Yuen KY
  • J Hosp Infect 2020[Oct]; 106 (2): 226-231 PMID32652214show ga
  • BACKGROUND: In late 2019, a novel human coronavirus - severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) - emerged in Wuhan, China. This virus has caused a global pandemic involving more than 200 countries. SARS-CoV-2 is highly adapted to humans and readily transmits from person-to-person. AIM: To investigate the infectivity of SARS-CoV-2 under various environmental and pH conditions. The efficacies of various laboratory virus inactivation methods and home disinfectants against SARS-CoV-2 were investigated. METHODS: The residual virus in dried form or in solution was titrated on to Vero E6 cells on days 0, 1, 3, 5 and 7 after incubation at different temperatures. Viral viability was determined after treatment with various disinfectants and pH solutions at room temperature (20-25(o)C). FINDINGS: SARS-CoV-2 was able to retain viability for 3-5 days in dried form or 7 days in solution at room temperature. SARS-CoV-2 could be detected under a wide range of pH conditions from pH 4 to pH 11 for several days, and for 1-2 days in stool at room temperature but lost 5 logs of infectivity. A variety of commonly used disinfectants and laboratory inactivation procedures were found to reduce viral viability effectively. CONCLUSION: This study demonstrated the stability of SARS-CoV-2 on environmental surfaces, and raises the possibility of faecal-oral transmission. Commonly used fixatives, nucleic acid extraction methods and heat inactivation were found to reduce viral infectivity significantly, which could ensure hospital and laboratory safety during the SARS-CoV-2 pandemic.
  • |*Microbial Viability[MESH]
  • |*Virulence[MESH]
  • |*Virus Inactivation[MESH]
  • |Betacoronavirus/*growth & development/*pathogenicity[MESH]
  • |China/epidemiology[MESH]
  • |Coronavirus Infections/epidemiology/*physiopathology[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/epidemiology/*physiopathology[MESH]
  • |Severe Acute Respiratory Syndrome/epidemiology/*pathology[MESH]


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  • suck abstract from ncbi

    226 2.106 2020