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10.1016/j.ymthe.2020.06.026 http://scihub22266oqcxt.onion/10.1016/j.ymthe.2020.06.026 32652045!7351027!32652045     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Ther 2020 ; 28 (10): 2203-2219 Nephropedia Template TP {{tp|p=32652045|t=2020. Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice |pdf=|usr=}}{{32652045}} gab.com Text Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice JO: Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=32652045 #FOAvip Mesenchymal stem/stromal cells (MSCs) are cultured adult stem cells that originally reside in virtually all tissues, and the gain of MSCs by transplantation has become the leading form of cell therapy in various diseases. However, there is limited knowledge on the alteration of its efficacy by factors in recipients. Here, we report that the cardioprotective properties of intravenously injected MSCs in a mouse model of pressure-overload heart failure largely depend on circulating adiponectin, an adipocyte-secreted factor. The injected MSCs exert their function through exosomes, extracellular vesicles of endosome origin. Adiponectin stimulated exosome biogenesis and secretion through binding to T-cadherin, a unique glycosylphosphatidylinositol-anchored cadherin, on MSCs. A pharmacological or adenovirus-mediated genetic increase in plasma adiponectin enhanced the therapeutic efficacy of MSCs. Our findings provide novel insights into the importance of adiponectin in mesenchymal-progenitor-mediated organ protections. Twit Text FOAVip Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice ????Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=32652045 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32652045 #FOAvip English Wikipedia <ref>{{Cite pmid|32652045}}</ref> Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice #MMPMID32652045 Nakamura Y; Kita S; Tanaka Y; Fukuda S; Obata Y; Okita T; Nishida H; Takahashi Y; Kawachi Y; Tsugawa-Shimizu Y; Fujishima Y; Nishizawa H; Takakura Y; Miyagawa S; Sawa Y; Maeda N; Shimomura I Mol Ther 2020[Oct]; 28 (10): 2203-2219 PMID32652045show ga Mesenchymal stem/stromal cells (MSCs) are cultured adult stem cells that originally reside in virtually all tissues, and the gain of MSCs by transplantation has become the leading form of cell therapy in various diseases. However, there is limited knowledge on the alteration of its efficacy by factors in recipients. Here, we report that the cardioprotective properties of intravenously injected MSCs in a mouse model of pressure-overload heart failure largely depend on circulating adiponectin, an adipocyte-secreted factor. The injected MSCs exert their function through exosomes, extracellular vesicles of endosome origin. Adiponectin stimulated exosome biogenesis and secretion through binding to T-cadherin, a unique glycosylphosphatidylinositol-anchored cadherin, on MSCs. A pharmacological or adenovirus-mediated genetic increase in plasma adiponectin enhanced the therapeutic efficacy of MSCs. Our findings provide novel insights into the importance of adiponectin in mesenchymal-progenitor-mediated organ protections. |*Mesenchymal Stem Cell Transplantation[MESH] |Adiponectin/blood/*genetics/metabolism[MESH] |Animals[MESH] |Cadherins/metabolism[MESH] |Cells, Cultured[MESH] |Disease Models, Animal[MESH] |Disease Susceptibility[MESH] |Exosomes/*metabolism[MESH] |Extracellular Vesicles/metabolism[MESH] |Heart Failure/etiology/physiopathology/*therapy[MESH] |Humans[MESH] |Mesenchymal Stem Cells/*metabolism[MESH]Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cel(epmc).pdf DeepDyve Pubget Overpricing