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Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Med 2020 ; 26 (9): 1422-1427 Nephropedia Template TP
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Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein #MMPMID32651581
Zost SJ; Gilchuk P; Chen RE; Case JB; Reidy JX; Trivette A; Nargi RS; Sutton RE; Suryadevara N; Chen EC; Binshtein E; Shrihari S; Ostrowski M; Chu HY; Didier JE; MacRenaris KW; Jones T; Day S; Myers L; Eun-Hyung Lee F; Nguyen DC; Sanz I; Martinez DR; Rothlauf PW; Bloyet LM; Whelan SPJ; Baric RS; Thackray LB; Diamond MS; Carnahan RH; Crowe JE Jr
Nat Med 2020[Sep]; 26 (9): 1422-1427 PMID32651581show ga
Antibodies are a principal determinant of immunity for most RNA viruses and have promise to reduce infection or disease during major epidemics. The novel coronavirus SARS-CoV-2 has caused a global pandemic with millions of infections and hundreds of thousands of deaths to date(1,2). In response, we used a rapid antibody discovery platform to isolate hundreds of human monoclonal antibodies (mAbs) against the SARS-CoV-2 spike (S) protein. We stratify these mAbs into five major classes on the basis of their reactivity to subdomains of S protein as well as their cross-reactivity to SARS-CoV. Many of these mAbs inhibit infection of authentic SARS-CoV-2 virus, with most neutralizing mAbs recognizing the receptor-binding domain (RBD) of S. This work defines sites of vulnerability on SARS-CoV-2 S and demonstrates the speed and robustness of advanced antibody discovery platforms.