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10.1126/sciimmunol.abd1554 http://scihub22266oqcxt.onion/10.1126/sciimmunol.abd1554 32651212!7402635!32651212     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Immunol 2020 ; 5 (49): ä Nephropedia Template TP {{tp|p=32651212|t=2020. Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 |pdf=|usr=}}{{32651212}} gab.com Text Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32651212 #FOAvip Although most SARS-CoV-2-infected individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer from severe COVID-19, which is accompanied by acute respiratory distress syndrome and systemic inflammation. To identify factors driving severe progression of COVID-19, we performed single-cell RNA-seq using peripheral blood mononuclear cells (PBMCs) obtained from healthy donors, patients with mild or severe COVID-19, and patients with severe influenza. Patients with COVID-19 exhibited hyper-inflammatory signatures across all types of cells among PBMCs, particularly up-regulation of the TNF/IL-1beta-driven inflammatory response as compared to severe influenza. In classical monocytes from patients with severe COVID-19, type I IFN response co-existed with the TNF/IL-1beta-driven inflammation, and this was not seen in patients with milder COVID-19. Interestingly, we documented type I IFN-driven inflammatory features in patients with severe influenza as well. Based on this, we propose that the type I IFN response plays a pivotal role in exacerbating inflammation in severe COVID-19. Twit Text FOAVip Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32651212 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32651212 #FOAvip English Wikipedia <ref>{{Cite pmid|32651212}}</ref> Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 #MMPMID32651212 Lee JS; Park S; Jeong HW; Ahn JY; Choi SJ; Lee H; Choi B; Nam SK; Sa M; Kwon JS; Jeong SJ; Lee HK; Park SH; Park SH; Choi JY; Kim SH; Jung I; Shin EC Sci Immunol 2020[Jul]; 5 (49): ä PMID32651212show ga Although most SARS-CoV-2-infected individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer from severe COVID-19, which is accompanied by acute respiratory distress syndrome and systemic inflammation. To identify factors driving severe progression of COVID-19, we performed single-cell RNA-seq using peripheral blood mononuclear cells (PBMCs) obtained from healthy donors, patients with mild or severe COVID-19, and patients with severe influenza. Patients with COVID-19 exhibited hyper-inflammatory signatures across all types of cells among PBMCs, particularly up-regulation of the TNF/IL-1beta-driven inflammatory response as compared to severe influenza. In classical monocytes from patients with severe COVID-19, type I IFN response co-existed with the TNF/IL-1beta-driven inflammation, and this was not seen in patients with milder COVID-19. Interestingly, we documented type I IFN-driven inflammatory features in patients with severe influenza as well. Based on this, we propose that the type I IFN response plays a pivotal role in exacerbating inflammation in severe COVID-19. |*Immunophenotyping[MESH] |*Severity of Illness Index[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Betacoronavirus/*genetics/*immunology[MESH] |CD8-Positive T-Lymphocytes/immunology[MESH] |COVID-19[MESH] |Cells, Cultured[MESH] |Coronavirus Infections/blood/*immunology/virology[MESH] |Female[MESH] |Healthy Volunteers[MESH] |Humans[MESH] |Inflammation/immunology[MESH] |Influenza A virus/*immunology[MESH] |Influenza, Human/blood/*immunology/virology[MESH] |Interferon Type I/*metabolism[MESH] |Interleukin-1beta/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*immunology/virology[MESH] |RNA-Seq[MESH] |SARS-CoV-2[MESH] |Single-Cell Analysis[MESH] |Transcriptome[MESH]Immunophenotyping of COVID-19 and influenza highlights the role of typ(epmc).pdf DeepDyve Pubget Overpricing