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10.1016/j.semerg.2020.06.010 http://scihub22266oqcxt.onion/10.1016/j.semerg.2020.06.010 32651152!7309836!32651152     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Semergen 2020 ; 46 Suppl 1 (ä): 6-11 Nephropedia Template TP {{tp|p=32651152|t=2020. Predictive factors of COVID-19 in patients with negative RT-qPCR |pdf=|usr=}}{{32651152}} gab.com Text Predictive factors of COVID-19 in patients with negative RT-qPCR JO: Semergen http://www.kidney.de/pget.php?&tw=1&pmid=32651152 #FOAvip OBJECTIVE: To evaluate the factors associated with false negatives in RT-qPCR in patients with mild-moderate symptoms of COVID-19. MATERIALS AND METHODS: This was a cross-sectional study that used a random sample of non-hospitalized patients from the primary care management division of the Healthcare Area of Leon (58 RT-qPCR-positive cases and 52 RT-qPCR-negative cases). Information regarding symptoms was collected and all patients were simultaneously tested using two rapid diagnostic tests - RDTs (Combined - cRDT and Differentiated - dRDT). The association between symptoms and SARS-CoV-2 infection was evaluated by non-conditional logistic regression, with estimation of Odds Ratio. RESULTS: A total of 110 subjects were studied, 52% of whom were women (mean age: 48.2+/-11.0 years). There were 42.3% of negative RT-qPCRs that were positive in some RDTs. Fever over 38 degrees C (present in 35.5% of cases) and anosmia (present in 41.8%) were the symptoms most associated with SARS-CoV-2 infection, a relationship that remained statistically significant in patients with negative RT-qPCR and some positive RDT (aOR=6.64; 95%CI=1.33-33.13 and aOR=19.38; 95% CI=3.69-101.89, respectively). CONCLUSIONS: RT-qPCR is the technique of choice in the diagnosis of SARS-CoV-2 infection, but it is not exempt from false negatives. Our results show that patients who present mild or moderate symptoms with negative RT-qPCR, but with fever and/or anosmia, should be considered as suspicious cases and should be evaluated with other diagnostic methods. Twit Text FOAVip Predictive factors of COVID-19 in patients with negative RT-qPCR ????Semergen http://www.kidney.de/pget.php?&tw=1&pmid=32651152 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32651152 #FOAvip English Wikipedia <ref>{{Cite pmid|32651152}}</ref> Predictive factors of COVID-19 in patients with negative RT-qPCR #MMPMID32651152 Lopez de la Iglesia J; Fernandez-Villa T; Rivero A; Carvajal A; Bay Simon E; Martinez Martinez M; Arguello H; Puente H; Fernandez Vazquez JP Semergen 2020[Aug]; 46 Suppl 1 (ä): 6-11 PMID32651152show ga OBJECTIVE: To evaluate the factors associated with false negatives in RT-qPCR in patients with mild-moderate symptoms of COVID-19. MATERIALS AND METHODS: This was a cross-sectional study that used a random sample of non-hospitalized patients from the primary care management division of the Healthcare Area of Leon (58 RT-qPCR-positive cases and 52 RT-qPCR-negative cases). Information regarding symptoms was collected and all patients were simultaneously tested using two rapid diagnostic tests - RDTs (Combined - cRDT and Differentiated - dRDT). The association between symptoms and SARS-CoV-2 infection was evaluated by non-conditional logistic regression, with estimation of Odds Ratio. RESULTS: A total of 110 subjects were studied, 52% of whom were women (mean age: 48.2+/-11.0 years). There were 42.3% of negative RT-qPCRs that were positive in some RDTs. Fever over 38 degrees C (present in 35.5% of cases) and anosmia (present in 41.8%) were the symptoms most associated with SARS-CoV-2 infection, a relationship that remained statistically significant in patients with negative RT-qPCR and some positive RDT (aOR=6.64; 95%CI=1.33-33.13 and aOR=19.38; 95% CI=3.69-101.89, respectively). CONCLUSIONS: RT-qPCR is the technique of choice in the diagnosis of SARS-CoV-2 infection, but it is not exempt from false negatives. Our results show that patients who present mild or moderate symptoms with negative RT-qPCR, but with fever and/or anosmia, should be considered as suspicious cases and should be evaluated with other diagnostic methods. |*Clinical Laboratory Techniques[MESH] |Adult[MESH] |COVID-19[MESH] |COVID-19 Testing[MESH] |Coronavirus Infections/*diagnosis[MESH] |Cross-Sectional Studies[MESH] |False Negative Reactions[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*diagnosis[MESH]Predictive factors of COVID-19 in patients with negative RT-qPCR (epmc).pdf DeepDyve Pubget Overpricing