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10.1016/j.rbmo.2020.06.001

http://scihub22266oqcxt.onion/10.1016/j.rbmo.2020.06.001
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32651106!7293848!32651106
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suck abstract from ncbi


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pmid32651106      Reprod+Biomed+Online 2020 ; 41 (3): 483-499
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  • Testing for SARS-CoV-2 (COVID-19): a systematic review and clinical guide to molecular and serological in-vitro diagnostic assays #MMPMID32651106
  • La Marca A; Capuzzo M; Paglia T; Roli L; Trenti T; Nelson SM
  • Reprod Biomed Online 2020[Sep]; 41 (3): 483-499 PMID32651106show ga
  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated coronavirus disease 2019 (COVID-19) pandemic has demanded rapid upscaling of in-vitro diagnostic assays to enable mass screening and testing of high-risk groups, and simultaneous ascertainment of robust data on past SARS-CoV-2 exposure at an individual and a population level. To meet the exponential demand in testing, there has been an accelerated development of both molecular and serological assays across a plethora of platforms. The present review discusses the current literature on these modalities, including nucleic acid amplification tests, direct viral antigen tests and the rapidly expanding laboratory-based and point of care serological tests. This suite of complementary tests will inform crucial decisions by healthcare providers and policy makers, and understanding their strengths and limitations will be critical to their judicious application for the development of algorithmic approaches to treatment and public health strategies.
  • |*Betacoronavirus/genetics/immunology[MESH]
  • |Antigens, Viral/analysis[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Centers for Disease Control and Prevention, U.S.[MESH]
  • |Clinical Laboratory Techniques/*methods[MESH]
  • |Coronavirus Infections/*diagnosis[MESH]
  • |False Negative Reactions[MESH]
  • |Humans[MESH]
  • |Mass Screening[MESH]
  • |Nasopharynx/virology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis[MESH]
  • |PubMed[MESH]
  • |RNA, Viral/analysis[MESH]
  • |SARS-CoV-2[MESH]
  • |Sensitivity and Specificity[MESH]
  • |Serologic Tests[MESH]
  • |Specimen Handling/methods[MESH]
  • |United States[MESH]


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