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10.1016/j.patol.2020.04.002

http://scihub22266oqcxt.onion/10.1016/j.patol.2020.04.002
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suck abstract from ncbi


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pmid32650970      Rev+Esp+Patol 2020 ; 53 (3): 188-192
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  • Autopsy findings from the first known death from Severe Acute Respiratory Syndrome SARS-CoV-2 in Spain #MMPMID32650970
  • Navarro Conde P; Alemany Monraval P; Medina Medina C; Jimenez Sanchez A; Andres Teruel JC; Ferrando Marco J; Puglia Santos V; Mayordomo Aranda E
  • Rev Esp Patol 2020[Jul]; 53 (3): 188-192 PMID32650970show ga
  • The new coronavirus SARS-CoV-2, first identified in Wuhan, China in December, 2019, can cause Severe Acute Respiratory Syndrome (SARS) with massive alveolar damage and progressive respiratory failure. We present the relevant autopsy findings of the first patient known to have died from COVID19 pneumonia in Spain, carried out on the 14(th) of February, 2020, in our hospital (Hospital Arnau de Vilanova-Lliria, Valencia). Histological examination revealed typical changes of diffuse alveolar damage (DAD) in both the exudative and proliferative phase of acute lung injury. Intra-alveolar multinucleated giant cells, smudge cells and vascular thrombosis were present. The diagnosis was confirmed by reverse real-time PCR assay on a throat swab sample taken during the patient's admission. The positive result was reported fifteen days subsequent to autopsy.
  • |*Autopsy[MESH]
  • |*Betacoronavirus/isolation & purification[MESH]
  • |*Pandemics[MESH]
  • |Aged[MESH]
  • |Alveolar Epithelial Cells/ultrastructure[MESH]
  • |Anion Exchange Protein 1, Erythrocyte/analysis[MESH]
  • |Antigens, CD/analysis[MESH]
  • |Antigens, Differentiation, Myelomonocytic/analysis[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Carcinoma, Transitional Cell/complications[MESH]
  • |China[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Community-Acquired Infections/diagnosis[MESH]
  • |Coronavirus Infections/complications/diagnosis/epidemiology/*pathology[MESH]
  • |DNA-Binding Proteins/analysis[MESH]
  • |Humans[MESH]
  • |Lung/*pathology/virology[MESH]
  • |Macrophages/chemistry/ultrastructure[MESH]
  • |Male[MESH]
  • |Pneumonia, Viral/complications/diagnosis/epidemiology/*pathology[MESH]
  • |Pneumonia/diagnosis[MESH]
  • |Respiratory Distress Syndrome/*etiology/pathology[MESH]
  • |SARS-CoV-2[MESH]
  • |Spain/epidemiology[MESH]
  • |Transcription Factors/analysis[MESH]
  • |Travel[MESH]


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