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10.1016/j.devcel.2020.06.022 http://scihub22266oqcxt.onion/10.1016/j.devcel.2020.06.022 32649861!7346820!32649861     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dev+Cell 2020 ; 54 (2): 142-155 Nephropedia Template TP {{tp|p=32649861|t=2020. Exaptive Evolution of Target of Rapamycin Signaling in Multicellular Eukaryotes |pdf=|usr=}}{{32649861}} gab.com Text Exaptive Evolution of Target of Rapamycin Signaling in Multicellular Eukaryotes JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=32649861 #FOAvip Target of rapamycin (TOR) is a protein kinase that coordinates metabolism with nutrient and energy availability in eukaryotes. TOR and its primary interactors, RAPTOR and LST8, have been remarkably evolutionarily static since they arose in the unicellular last common ancestor of plants, fungi, and animals, but the upstream regulatory mechanisms and downstream effectors of TOR signaling have evolved considerable diversity in these separate lineages. Here, I focus on the roles of exaptation and adaptation in the evolution of novel signaling axes in the TOR network in multicellular eukaryotes, concentrating especially on amino acid sensing, cell-cell signaling, and cell differentiation. Twit Text FOAVip Exaptive Evolution of Target of Rapamycin Signaling in Multicellular Eukaryotes ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=32649861 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32649861 #FOAvip English Wikipedia <ref>{{Cite pmid|32649861}}</ref> Exaptive Evolution of Target of Rapamycin Signaling in Multicellular Eukaryotes #MMPMID32649861 Brunkard JO Dev Cell 2020[Jul]; 54 (2): 142-155 PMID32649861show ga Target of rapamycin (TOR) is a protein kinase that coordinates metabolism with nutrient and energy availability in eukaryotes. TOR and its primary interactors, RAPTOR and LST8, have been remarkably evolutionarily static since they arose in the unicellular last common ancestor of plants, fungi, and animals, but the upstream regulatory mechanisms and downstream effectors of TOR signaling have evolved considerable diversity in these separate lineages. Here, I focus on the roles of exaptation and adaptation in the evolution of novel signaling axes in the TOR network in multicellular eukaryotes, concentrating especially on amino acid sensing, cell-cell signaling, and cell differentiation. |Amino Acids/metabolism[MESH] |Animals[MESH] |Eukaryota/*drug effects/metabolism[MESH] |Signal Transduction/*drug effects/physiology[MESH] |Sirolimus/*pharmacology[MESH]Exaptive Evolution of Target of Rapamycin Signaling in Multicellular E(epmc).pdf DeepDyve Pubget Overpricing