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10.1080/17474124.2020.1794812

http://scihub22266oqcxt.onion/10.1080/17474124.2020.1794812
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32649840!ä!32649840

suck abstract from ncbi


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pmid32649840      Expert+Rev+Gastroenterol+Hepatol 2020 ; 14 (10): 879-884
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  • Liver injury in severe COVID-19 infection: current insights and challenges #MMPMID32649840
  • Ali N; Hossain K
  • Expert Rev Gastroenterol Hepatol 2020[Oct]; 14 (10): 879-884 PMID32649840show ga
  • INTRODUCTION: The outbreak of COVID-19 is a serious health threat worldwide. Different degrees of liver injury or liver dysfunctions have been reported in patients with COVID-19 infection. However, currently, it remains unclear to what extent liver diseases should be considered as significant risk factors for the severity and mortality of COVID-19. Moreover, the mechanisms involved in liver injury in severe COVID-19 infection are not yet well understood. AREA COVERED: This review summarizes the current evidence on liver function abnormalities in COVID-19 patients and the effects of preexisting liver disease on the disease severity. This review also illustrates the possible underlying mechanisms linking COVID-19 to liver injury, as well as provides recommendations to prevent liver damage in COVID-19 infection. EXPERT OPINION: The elevated levels of ALT, AST, GGT and bilirubin are common in more severe patients than non-severe or mild COVID-19 patients. Patients with preexisting medical conditions including chronic hepatic diseases are at higher risk for severe illness from COVID-19 infection. The drug's effects, possible viral inclusion in liver cells, systemic inflammation and hypoxia are potential causes of liver injury in severe COVID-19. Nevertheless, further studies are needed focusing on the preexisting hepatic diseases on prevention, treatment and outcome of COVID-19.
  • |*Betacoronavirus[MESH]
  • |*Pandemics[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*complications/epidemiology[MESH]
  • |Global Health[MESH]
  • |Humans[MESH]
  • |Liver Diseases/diagnosis/epidemiology/*etiology[MESH]
  • |Liver Function Tests[MESH]
  • |Morbidity/trends[MESH]
  • |Pneumonia, Viral/*complications/epidemiology[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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