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10.1038/s41375-020-0959-x http://scihub22266oqcxt.onion/10.1038/s41375-020-0959-x 32647324!7347048!32647324     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Leukemia 2020 ; 34 (9): 2354-2363 Nephropedia Template TP {{tp|p=32647324|t=2020. COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus |pdf=|usr=}}{{32647324}} gab.com Text COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus JO: Leukemia http://www.kidney.de/pget.php?&tw=1&pmid=32647324 #FOAvip Chronic lymphocytic leukemia (CLL) is a disease of the elderly, characterized by immunodeficiency. Hence, patients with CLL might be considered more susceptible to severe complications from COVID-19. We undertook this retrospective international multicenter study to characterize the course of COVID-19 in patients with CLL and identify potential predictors of outcome. Of 190 patients with CLL and confirmed COVID-19 diagnosed between 28/03/2020 and 22/05/2020, 151 (79%) presented with severe COVID-19 (need of oxygen and/or intensive care admission). Severe COVID-19 was associated with more advanced age (>/=65 years) (odds ratio 3.72 [95% CI 1.79-7.71]). Only 60 patients (39.7%) with severe COVID-19 were receiving or had recent (</=12 months) treatment for CLL at the time of COVID-19 versus 30/39 (76.9%) patients with mild disease. Hospitalization rate for severe COVID-19 was lower (p < 0.05) for patients on ibrutinib versus those on other regimens or off treatment. Of 151 patients with severe disease, 55 (36.4%) succumbed versus only 1/38 (2.6%) with mild disease; age and comorbidities did not impact on mortality. In CLL, (1) COVID-19 severity increases with age; (2) antileukemic treatment (particularly BTK inhibitors) appears to exert a protective effect; (3) age and comorbidities did not impact on mortality, alluding to a relevant role of CLL and immunodeficiency. Twit Text FOAVip COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus ????Leukemia http://www.kidney.de/pget.php?&tw=1&pmid=32647324 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32647324 #FOAvip English Wikipedia <ref>{{Cite pmid|32647324}}</ref> COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus #MMPMID32647324 Scarfo L; Chatzikonstantinou T; Rigolin GM; Quaresmini G; Motta M; Vitale C; Garcia-Marco JA; Hernandez-Rivas JA; Miras F; Baile M; Marquet J; Niemann CU; Reda G; Munir T; Gimeno E; Marchetti M; Quaglia FM; Varettoni M; Delgado J; Iyengar S; Janssens A; Marasca R; Ferrari A; Cuellar-Garcia C; Itchaki G; Spacek M; De Paoli L; Laurenti L; Levin MD; Lista E; Mauro FR; Simkovic M; Van Der Spek E; Vandenberghe E; Trentin L; Wasik-Szczepanek E; Ruchlemer R; Bron D; De Paolis MR; Del Poeta G; Farina L; Foglietta M; Gentile M; Herishanu Y; Herold T; Jaksic O; Kater AP; Kersting S; Malerba L; Orsucci L; Popov VM; Sportoletti P; Yassin M; Pocali B; Barna G; Chiarenza A; Dos Santos G; Nikitin E; Andres M; Dimou M; Doubek M; Enrico A; Hakobyan Y; Kalashnikova O; Ortiz Pareja M; Papaioannou M; Rossi D; Shah N; Shrestha A; Stanca O; Stavroyianni N; Strugov V; Tam C; Zdrenghea M; Coscia M; Stamatopoulos K; Rossi G; Rambaldi A; Montserrat E; Foa R; Cuneo A; Ghia P Leukemia 2020[Sep]; 34 (9): 2354-2363 PMID32647324show ga Chronic lymphocytic leukemia (CLL) is a disease of the elderly, characterized by immunodeficiency. Hence, patients with CLL might be considered more susceptible to severe complications from COVID-19. We undertook this retrospective international multicenter study to characterize the course of COVID-19 in patients with CLL and identify potential predictors of outcome. Of 190 patients with CLL and confirmed COVID-19 diagnosed between 28/03/2020 and 22/05/2020, 151 (79%) presented with severe COVID-19 (need of oxygen and/or intensive care admission). Severe COVID-19 was associated with more advanced age (>/=65 years) (odds ratio 3.72 [95% CI 1.79-7.71]). Only 60 patients (39.7%) with severe COVID-19 were receiving or had recent ( |*Betacoronavirus[MESH] |Adenine/analogs & derivatives[MESH] |Age Factors[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antineoplastic Agents/pharmacology/therapeutic use[MESH] |COVID-19[MESH] |Comorbidity[MESH] |Coronavirus Infections/diagnosis/mortality/*pathology[MESH] |Female[MESH] |Humans[MESH] |Leukemia, Lymphocytic, Chronic, B-Cell/*complications/drug therapy[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Piperidines[MESH] |Pneumonia, Viral/diagnosis/mortality/*pathology[MESH] |Prognosis[MESH] |Protein Kinase Inhibitors/pharmacology/therapeutic use[MESH] |Pyrazoles/pharmacology/therapeutic use[MESH] |Pyrimidines/pharmacology/therapeutic use[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH]COVID-19 severity and mortality in patients with chronic lymphocytic l(epmc).pdf DeepDyve Pubget Overpricing