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10.1038/s41467-020-17409-9 http://scihub22266oqcxt.onion/10.1038/s41467-020-17409-9 32647131!7347890!32647131     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 3523 Nephropedia Template TP {{tp|p=32647131|t=2020. Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice |pdf=|usr=}}{{32647131}} gab.com Text Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32647131 #FOAvip The spread of the SARS-CoV-2 into a global pandemic within a few months of onset motivates the development of a rapidly scalable vaccine. Here, we present a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle (LNP) as a vaccine. We observe remarkably high and dose-dependent SARS-CoV-2 specific antibody titers in mouse sera, as well as robust neutralization of both a pseudo-virus and wild-type virus. Upon further characterization we find that the neutralization is proportional to the quantity of specific IgG and of higher magnitude than recovered COVID-19 patients. saRNA LNP immunizations induce a Th1-biased response in mice, and there is no antibody-dependent enhancement (ADE) observed. Finally, we observe high cellular responses, as characterized by IFN-gamma production, upon re-stimulation with SARS-CoV-2 peptides. These data provide insight into the vaccine design and evaluation of immunogenicity to enable rapid translation to the clinic. Twit Text FOAVip Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32647131 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32647131 #FOAvip English Wikipedia <ref>{{Cite pmid|32647131}}</ref> Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice #MMPMID32647131 McKay PF; Hu K; Blakney AK; Samnuan K; Brown JC; Penn R; Zhou J; Bouton CR; Rogers P; Polra K; Lin PJC; Barbosa C; Tam YK; Barclay WS; Shattock RJ Nat Commun 2020[Jul]; 11 (1): 3523 PMID32647131show ga The spread of the SARS-CoV-2 into a global pandemic within a few months of onset motivates the development of a rapidly scalable vaccine. Here, we present a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle (LNP) as a vaccine. We observe remarkably high and dose-dependent SARS-CoV-2 specific antibody titers in mouse sera, as well as robust neutralization of both a pseudo-virus and wild-type virus. Upon further characterization we find that the neutralization is proportional to the quantity of specific IgG and of higher magnitude than recovered COVID-19 patients. saRNA LNP immunizations induce a Th1-biased response in mice, and there is no antibody-dependent enhancement (ADE) observed. Finally, we observe high cellular responses, as characterized by IFN-gamma production, upon re-stimulation with SARS-CoV-2 peptides. These data provide insight into the vaccine design and evaluation of immunogenicity to enable rapid translation to the clinic. |Animals[MESH] |Antibodies, Neutralizing/*immunology[MESH] |Antibodies, Viral/blood/metabolism[MESH] |Antibody-Dependent Enhancement/immunology[MESH] |Betacoronavirus/genetics/*immunology[MESH] |COVID-19[MESH] |COVID-19 Vaccines[MESH] |Coronavirus Infections/immunology/*prevention & control/virology[MESH] |Cytokines/immunology[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Immunity, Cellular[MESH] |Immunoglobulin G/blood[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Nanoparticles/*chemistry[MESH] |Pandemics/*prevention & control[MESH] |Pneumonia, Viral/immunology/*prevention & control/virology[MESH] |RNA, Viral/immunology[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/genetics/immunology[MESH] |Vaccines, Synthetic/chemistry/immunology[MESH]Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate in(epmc).pdf DeepDyve Pubget Overpricing