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10.1016/j.mehy.2020.110074 http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.110074 32645661!7333600!32645661     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Hypotheses 2020 ; 143 (ä): 110074 Nephropedia Template TP {{tp|p=32645661|t=2020. Is the presence of lung injury in COVID-19 an independent risk factor for secondary lung cancer?|pdf=|usr=}}{{32645661}} gab.com Text Is the presence of lung injury in COVID-19 an independent risk factor for secondary lung cancer JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32645661 #FOAvip The morbidity and mortality of lung cancer are increasing. The Corona Virus Disease 2019 (COVID-19) is caused by novel coronavirus 2019-nCoV-2, leading to subsequent pulmonary interstitial fibrosis with chronic inflammatory changes, e.g., inflammatory factors repeatedly continuously stimulating and attacking the alveolar epithelial cells. Meanwhile, 2019-nCoV-2 can activate PI3K/Akt and ERK signaling pathways, which can play the double roles as both anti-inflammatory and carcinogenic factors. Moreover, hypoxemia may be developed, resulting in the up-regulation of HIF-1 alpha expression, which can be involved in the occurrence, angiogenesis, invasion and metastasis of lung cancer. Additionally, the immune system in 2019-nCoV-2 infected cases can be suppressed to cause tumor immune evasion. Therefore, we speculate that COVID-19 may be a risk factor of secondary lung cancer. Twit Text FOAVip Is the presence of lung injury in COVID-19 an independent risk factor for secondary lung cancer ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32645661 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32645661 #FOAvip English Wikipedia <ref>{{Cite pmid|32645661}}</ref> Is the presence of lung injury in COVID-19 an independent risk factor for secondary lung cancer? #MMPMID32645661 Tao SL; Wang XM; Feng YG; Kang PM; Li QY; Sun TY; Tan QY; Deng B Med Hypotheses 2020[Oct]; 143 (ä): 110074 PMID32645661show ga The morbidity and mortality of lung cancer are increasing. The Corona Virus Disease 2019 (COVID-19) is caused by novel coronavirus 2019-nCoV-2, leading to subsequent pulmonary interstitial fibrosis with chronic inflammatory changes, e.g., inflammatory factors repeatedly continuously stimulating and attacking the alveolar epithelial cells. Meanwhile, 2019-nCoV-2 can activate PI3K/Akt and ERK signaling pathways, which can play the double roles as both anti-inflammatory and carcinogenic factors. Moreover, hypoxemia may be developed, resulting in the up-regulation of HIF-1 alpha expression, which can be involved in the occurrence, angiogenesis, invasion and metastasis of lung cancer. Additionally, the immune system in 2019-nCoV-2 infected cases can be suppressed to cause tumor immune evasion. Therefore, we speculate that COVID-19 may be a risk factor of secondary lung cancer. |*Betacoronavirus/pathogenicity[MESH] |Angiotensin-Converting Enzyme 2[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications/epidemiology/immunology[MESH] |Host Microbial Interactions[MESH] |Humans[MESH] |Hypoxia/complications[MESH] |Lung Injury/*complications[MESH] |Lung Neoplasms/*etiology[MESH] |Models, Biological[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A[MESH] |Pneumonia, Viral/*complications/epidemiology/immunology[MESH] |Pulmonary Fibrosis/etiology[MESH] |Risk Factors[MESH] |SARS-CoV-2[MESH] |Signal Transduction[MESH]Is the presence of lung injury in COVID-19 an independent risk factor (epmc).pdf DeepDyve Pubget Overpricing