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10.1016/j.cca.2020.07.002 http://scihub22266oqcxt.onion/10.1016/j.cca.2020.07.002 32645391!7833652!32645391     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Chim+Acta 2020 ; 510 (ä): 47-53 Nephropedia Template TP {{tp|p=32645391|t=2020. Correlation between cytokines and coagulation-related parameters in patients with coronavirus disease 2019 admitted to ICU |pdf=|usr=}}{{32645391}} gab.com Text Correlation between cytokines and coagulation-related parameters in patients with coronavirus disease 2019 admitted to ICU JO: Clin Chim Acta http://www.kidney.de/pget.php?&tw=1&pmid=32645391 #FOAvip BACKGROUND: The novel SARS-CoV-2 caused a large number of infections and deaths worldwide. Thus, new ideas for an appropriated assessment of patients' condition and clinical treatment are of utmost importance. Therefore, in this study, the laboratory parameters of patients with coronavirus disease 2019 (COVID-19) were evaluated to identify the correlation between cytokine expression and other laboratory parameters. METHODS: A retrospective and single-center study was performed in Wuhan, involving 83 severe or critical COVID-19 patients admitted to the intensive care unit (ICU). Laboratory parameters in ICU patients with laboratory-confirmed infection of SARS-CoV2 were collected. The association between parameters was assessed by Spearman's rank correlation. RESULTS: Patients' median age was 66 years (IQR, 57-73), and 55 (66%) were men. Among the 83 patients, 61 (73%) had 1 or more coexisting medical condition. The median concentration of IL-2R, IL-6, IL8, IL10, and TNFalpha were above the normal range, without IL-1beta. A significant negative correlation between IL-6 and platelet count was discovered (r(2) = -0.448, P < 0.001) as well as a significant correlation between IL-6 and other platelet parameters. Finally, a correlation between multiple cytokines and coagulation indicators was found, pro-inflammatory factors were found to be more associated to coagulation parameters, with the highest correlation between IL-6 and the International normalized ratio (INR) (r(2) = 0.444, P < 0.001). CONCLUSIONS: Our results suggested that cytokines play an important role in the pathogenesis of COVID-19. In addition, IL-6 seems more relevant in the evaluation of the condition of COVID-19 patients. Twit Text FOAVip Correlation between cytokines and coagulation-related parameters in patients with coronavirus disease 2019 admitted to ICU ????Clin Chim Acta http://www.kidney.de/pget.php?&tw=1&pmid=32645391 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32645391 #FOAvip English Wikipedia <ref>{{Cite pmid|32645391}}</ref> Correlation between cytokines and coagulation-related parameters in patients with coronavirus disease 2019 admitted to ICU #MMPMID32645391 Zhang D; Zhou X; Yan S; Tian R; Su L; Ding X; Xiao M; Chen Y; Zhao H; Chen H; Zhang H; Li Z; Li Q; Xu Y; Yan X; Li Y; Zhang S Clin Chim Acta 2020[Nov]; 510 (ä): 47-53 PMID32645391show ga BACKGROUND: The novel SARS-CoV-2 caused a large number of infections and deaths worldwide. Thus, new ideas for an appropriated assessment of patients' condition and clinical treatment are of utmost importance. Therefore, in this study, the laboratory parameters of patients with coronavirus disease 2019 (COVID-19) were evaluated to identify the correlation between cytokine expression and other laboratory parameters. METHODS: A retrospective and single-center study was performed in Wuhan, involving 83 severe or critical COVID-19 patients admitted to the intensive care unit (ICU). Laboratory parameters in ICU patients with laboratory-confirmed infection of SARS-CoV2 were collected. The association between parameters was assessed by Spearman's rank correlation. RESULTS: Patients' median age was 66 years (IQR, 57-73), and 55 (66%) were men. Among the 83 patients, 61 (73%) had 1 or more coexisting medical condition. The median concentration of IL-2R, IL-6, IL8, IL10, and TNFalpha were above the normal range, without IL-1beta. A significant negative correlation between IL-6 and platelet count was discovered (r(2) = -0.448, P < 0.001) as well as a significant correlation between IL-6 and other platelet parameters. Finally, a correlation between multiple cytokines and coagulation indicators was found, pro-inflammatory factors were found to be more associated to coagulation parameters, with the highest correlation between IL-6 and the International normalized ratio (INR) (r(2) = 0.444, P < 0.001). CONCLUSIONS: Our results suggested that cytokines play an important role in the pathogenesis of COVID-19. In addition, IL-6 seems more relevant in the evaluation of the condition of COVID-19 patients. |*Blood Coagulation[MESH] |Aged[MESH] |COVID-19[MESH] |Coronavirus Infections/*metabolism/physiopathology/therapy[MESH] |Cytokines/*metabolism[MESH] |Female[MESH] |Humans[MESH] |Intensive Care Units/*statistics & numerical data[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Patient Admission/*statistics & numerical data[MESH] |Pneumonia, Viral/*metabolism/physiopathology/therapy[MESH]Correlation between cytokines and coagulation-related parameters in pa(epmc).pdf DeepDyve Pubget Overpricing