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10.1016/j.lfs.2020.118056 http://scihub22266oqcxt.onion/10.1016/j.lfs.2020.118056 32645344!7336130!32645344     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Life+Sci 2020 ; 257 (ä): 118056 Nephropedia Template TP {{tp|p=32645344|t=2020. Structural features of coronavirus SARS-CoV-2 spike protein: Targets for vaccination |pdf=|usr=}}{{32645344}} gab.com Text Structural features of coronavirus SARS-CoV-2 spike protein: Targets for vaccination JO: Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=32645344 #FOAvip Various human pathogenic viruses employ envelope glycoproteins for host cell receptor recognition and binding, membrane fusion and viral entry. The spike (S) glycoprotein of betacoronavirus SARS-CoV-2 is a homotrimeric class I fusion protein that exists in a metastable conformation for cleavage by host cell proteases furin and TMPRSS2, thereby undergoing substantial structural rearrangement for ACE2 host cell receptor binding and subsequent viral entry by membrane fusion. The S protein is densely decorated with N-linked glycans protruding from the trimer surface that affect S protein folding, processing by host cell proteases and the elicitation of humoral immune response. Deep insight into the sophisticated structure of SARS-CoV-2 S protein may provide a blueprint for vaccination strategies, as reviewed herein. Twit Text FOAVip Structural features of coronavirus SARS-CoV-2 spike protein: Targets for vaccination ????Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=32645344 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32645344 #FOAvip English Wikipedia <ref>{{Cite pmid|32645344}}</ref> Structural features of coronavirus SARS-CoV-2 spike protein: Targets for vaccination #MMPMID32645344 Sternberg A; Naujokat C Life Sci 2020[Sep]; 257 (ä): 118056 PMID32645344show ga Various human pathogenic viruses employ envelope glycoproteins for host cell receptor recognition and binding, membrane fusion and viral entry. The spike (S) glycoprotein of betacoronavirus SARS-CoV-2 is a homotrimeric class I fusion protein that exists in a metastable conformation for cleavage by host cell proteases furin and TMPRSS2, thereby undergoing substantial structural rearrangement for ACE2 host cell receptor binding and subsequent viral entry by membrane fusion. The S protein is densely decorated with N-linked glycans protruding from the trimer surface that affect S protein folding, processing by host cell proteases and the elicitation of humoral immune response. Deep insight into the sophisticated structure of SARS-CoV-2 S protein may provide a blueprint for vaccination strategies, as reviewed herein. |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/immunology/pathogenicity[MESH] |COVID-19[MESH] |Coronavirus Infections/*drug therapy/*immunology/pathology/prevention & control[MESH] |Humans[MESH] |Pandemics/prevention & control[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Pneumonia, Viral/*drug therapy/*immunology/pathology/prevention & control[MESH] |Protein Binding[MESH] |Receptors, Virus/metabolism[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/chemistry/*immunology/metabolism[MESH] |Vaccination/methods[MESH]Structural features of coronavirus SARS-CoV-2 spike protein: Targets f(epmc).pdf DeepDyve Pubget Overpricing