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10.1016/j.cell.2020.06.025

http://scihub22266oqcxt.onion/10.1016/j.cell.2020.06.025
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32645326!7311918!32645326
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suck abstract from ncbi


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pmid32645326      Cell 2020 ; 182 (4): 828-842.e16
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  • Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies #MMPMID32645326
  • Barnes CO; West AP Jr; Huey-Tubman KE; Hoffmann MAG; Sharaf NG; Hoffman PR; Koranda N; Gristick HB; Gaebler C; Muecksch F; Lorenzi JCC; Finkin S; Hagglof T; Hurley A; Millard KG; Weisblum Y; Schmidt F; Hatziioannou T; Bieniasz PD; Caskey M; Robbiani DF; Nussenzweig MC; Bjorkman PJ
  • Cell 2020[Aug]; 182 (4): 828-842.e16 PMID32645326show ga
  • Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain (RBD) of the trimeric spike. Here, we characterized polyclonal immunoglobulin Gs (IgGs) and Fabs from COVID-19 convalescent individuals for recognition of coronavirus spikes. Plasma IgGs differed in their focus on RBD epitopes, recognition of alpha- and beta-coronaviruses, and contributions of avidity to increased binding/neutralization of IgGs over Fabs. Using electron microscopy, we examined specificities of polyclonal plasma Fabs, revealing recognition of both S1(A) and RBD epitopes on SARS-CoV-2 spike. Moreover, a 3.4 A cryo-electron microscopy (cryo-EM) structure of a neutralizing monoclonal Fab-spike complex revealed an epitope that blocks ACE2 receptor binding. Modeling based on these structures suggested different potentials for inter-spike crosslinking by IgGs on viruses, and characterized IgGs would not be affected by identified SARS-CoV-2 spike mutations. Overall, our studies structurally define a recurrent anti-SARS-CoV-2 antibody class derived from VH3-53/VH3-66 and similarity to a SARS-CoV VH3-30 antibody, providing criteria for evaluating vaccine-elicited antibodies.
  • |Antibodies, Neutralizing/blood/*chemistry/isolation & purification[MESH]
  • |Antibodies, Viral/immunology/isolation & purification[MESH]
  • |Betacoronavirus/*chemistry/immunology[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |Coronavirus Infections/blood/*immunology/therapy[MESH]
  • |Cross Reactions[MESH]
  • |Cryoelectron Microscopy[MESH]
  • |Epitope Mapping[MESH]
  • |Epitopes[MESH]
  • |Humans[MESH]
  • |Immunization, Passive[MESH]
  • |Immunoglobulin Fab Fragments/blood/*chemistry/isolation & purification/ultrastructure[MESH]
  • |Immunoglobulin G/blood/*chemistry/isolation & purification/ultrastructure[MESH]
  • |Middle East Respiratory Syndrome Coronavirus/chemistry/immunology[MESH]
  • |Models, Molecular[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/blood/*immunology[MESH]
  • |SARS-CoV-2[MESH]
  • |Severe acute respiratory syndrome-related coronavirus/chemistry/immunology[MESH]


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