Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1016/j.cell.2020.06.010

http://scihub22266oqcxt.onion/10.1016/j.cell.2020.06.010
suck pdf from google scholar
32643603!7284240!32643603
unlimited free pdf from europmc32643603    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi


Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
pmid32643603      Cell 2020 ; 182 (3): 734-743.e5
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment #MMPMID32643603
  • Sun J; Zhuang Z; Zheng J; Li K; Wong RL; Liu D; Huang J; He J; Zhu A; Zhao J; Li X; Xi Y; Chen R; Alshukairi AN; Chen Z; Zhang Z; Chen C; Huang X; Li F; Lai X; Chen D; Wen L; Zhuo J; Zhang Y; Wang Y; Huang S; Dai J; Shi Y; Zheng K; Leidinger MR; Chen J; Li Y; Zhong N; Meyerholz DK; McCray PB Jr; Perlman S; Zhao J
  • Cell 2020[Aug]; 182 (3): 734-743.e5 PMID32643603show ga
  • COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with >4,000,000 confirmed cases worldwide and >290,000 deaths as of May 15, 2020. It is critical that vaccines and therapeutics be developed very rapidly. Mice, the ideal animal for assessing such interventions, are resistant to SARS-CoV-2. Here, we overcome this difficulty by exogenous delivery of human ACE2 with a replication-deficient adenovirus (Ad5-hACE2). Ad5-hACE2-sensitized mice developed pneumonia characterized by weight loss, severe pulmonary pathology, and high-titer virus replication in lungs. Type I interferon, T cells, and, most importantly, signal transducer and activator of transcription 1 (STAT1) are critical for virus clearance and disease resolution in these mice. Ad5-hACE2-transduced mice enabled rapid assessments of a vaccine candidate, of human convalescent plasma, and of two antiviral therapies (poly I:C and remdesivir). In summary, we describe a murine model of broad and immediate utility to investigate COVID-19 pathogenesis and to evaluate new therapies and vaccines.
  • |*Disease Models, Animal[MESH]
  • |*Vaccination[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Animals[MESH]
  • |Betacoronavirus/*immunology[MESH]
  • |COVID-19[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Coronavirus Infections/*pathology/*prevention & control/virology[MESH]
  • |Drug Evaluation, Preclinical/methods[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Interferon-gamma/genetics/metabolism[MESH]
  • |Lung/pathology/virology[MESH]
  • |Male[MESH]
  • |Mice[MESH]
  • |Mice, Inbred BALB C[MESH]
  • |Mice, Inbred C57BL[MESH]
  • |Mice, Knockout[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Peptidyl-Dipeptidase A/genetics/metabolism[MESH]
  • |Pneumonia, Viral/*pathology/*prevention & control/virology[MESH]
  • |Receptor, Interferon alpha-beta/genetics/metabolism[MESH]
  • |SARS-CoV-2[MESH]
  • |STAT1 Transcription Factor/genetics/metabolism[MESH]
  • |Specific Pathogen-Free Organisms[MESH]
  • |Transduction, Genetic[MESH]
  • |Vero Cells[MESH]
  • |Viral Load[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box